Deguelin Analysis Service

Deguelin is a natural flavonoid compound, belonging to the rotenoid derivatives, primarily found in leguminous plants such as Lonchocarpus, Derris, or Tephrosia species. Deguelin has the chemical formula C₂₃H₂₂O₆, with a molecular structure that includes multiple phenolic hydroxyl groups. Its structural features, such as polycyclic aromatic structures and an oxidized pyran ring, endow it with various biological activities. Deguelin exhibits significant effects in anticancer, anti-inflammatory, and antioxidant activities. Research indicates that deguelin can effectively inhibit tumor cell proliferation, induce apoptosis, and reduce cancer occurrence by suppressing multiple signaling pathways such as PI3K/Akt, NF-κB, and HIF-1α. Additionally, deguelin has neuroprotective properties and can be studied for neurodegenerative diseases. The anticancer activity of deguelin has been validated in various cancer models, including lung, breast, prostate, and colon cancers. It blocks critical survival signaling pathways in cancer cells, inhibiting their growth and invasiveness. Furthermore, deguelin can enhance the effects of radiotherapy and chemotherapy, making it a potential candidate for cancer treatment.

 



Figure 1. The Structure of Deguelin

 

MtoZ Biolabs is proud to offer a comprehensive Deguelin Analysis Service, leveraging our advanced high-performance liquid chromatography-mass spectrometry (HPLC-MS) platform and knowledgeable metabolomics team. Our service provides a thorough deguelin analysis, ensuring high sensitivity and accuracy.

 

Analysis Workflow

 



 

Service Advantages

1. Expert Team: Our team scientists have deep understanding and extensive experience in MS and metabolomics.

 

2. Advanced Techniques: We employ state-of-the-art HPLC-MS platforms that ensure high sensitivity and specificity of detection.

 

3. Customizable Service: Our service is flexible to accommodate specific research needs and goals.

 

4. Fast Turnaround Time: We strive to deliver results in a timely manner without compromising on the quality.

 

5. Data Confidentiality: We strictly adhere to data security and confidentiality protocols.

 

Applications

• Investigating the pharmacokinetics of deguelin
• Identifying potential therapeutic applications of deguelin
• Quality control of herbal medicine and health supplements
• Environmental monitoring

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissue homogenates, and other biological samples.

 

2. Sample Volume

At least 200 μL of liquid sample or 200 mg of solid sample.

 

3. Sample Preservation

Store at -80°C to maintain stability.

 

Note: Provide details on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Deguelin

4. Raw Data

5. Custom Analysis Report

 

Through our deguelin analysis service, we aim to support your research and product development initiatives by providing dependable and accurate results.