Ferroptosis Metabolism Analysis Service

Ferroptosis is an iron-dependent programmed cell death pathway, distinct from traditional forms like apoptosis, necrosis, or autophagy. This process is driven by the catalytic role of iron, leading to lethal accumulations of lipid peroxides. Specifically, inhibitors such as Erastin decrease cellular glutathione levels, inactivate GPX4, and intensify lipid peroxidation, culminating in cell death. Direct GPX4 inhibition, such as with RSL3, also induces ferroptosis. This pathway intersects with numerous cellular metabolic processes, including iron, polyunsaturated fatty acids, amino acids, and the synthesis of glutathione, phospholipids, NADPH, and coenzyme Q10. Ferroptosis is linked to a range of conditions including neurodegenerative diseases, cancer, and brain injuries.

 

 



Hao, S. et al. Oncol Lett. 2018.

Figure 1. Iron Metabolism in Ferroptosis

 

Services at MtoZ Biolabs

Utilizing state-of-the-art LC-MS technology, MtoZ Biolabs provides in-depth analysis of key ferroptosis metabolites such as ions, lipid peroxides, and glutathione, enhancing the pace of research and discovery.

We offer:

1. Untargeted Analysis

• Extensive metabolic profiling
• High-throughput identification of metabolites
• Metabolic pathway analysis
• Discovery and validation of novel biomarkers

 

2. Targeted Analysis

Standard curve creation, meticulous preprocessing of raw data, and precise quantification

 

Service Advantages

• Our ultra-sensitive assays can detect metabolites at the picogram level, allowing for the simultaneous analysis of multiple markers and increasing cost-effectiveness.
• Our team of metabolomics experts has vast experience with large-scale sample analysis, guaranteeing the accuracy and reliability of our data.
• We provide tailored solutions to meet the unique demands of ferroptosis research, ensuring that our services align perfectly with your project needs.
• Our platforms are suitable for both fundamental and translational research, including preclinical studies and drug development, particularly in elucidating disease mechanisms and validating therapeutic targets.

 

MtoZ Biolabs is dedicated to propelling your research with our advanced technological expertise. Should further metabolite analysis be required, our team is ready to offer all necessary support and consultation. We aspire to be a dependable ally in your research endeavors.