Fumaric Acid Analysis Service
- Measure levels of fumaric acid in patients to assist in diagnosing metabolic disorders, inflammation, and skin diseases.
- Monitor changes in fumaric acid levels to assess disease progression and treatment efficacy.
- Analyze the content of fumaric acid in food and nutritional supplements to guide dietary intake and supplementation strategies.
- Detect fumaric acid pollution in environmental samples to assess ecosystem health.
- Study the roles of fumaric acid in metabolic pathways to gain deeper insights into its biological functions and mechanisms.
Fumaric acid is a widely occurring organic acid in nature, especially in plants and fungi. It has a fruity taste and is commonly used as a food additive. Fumaric acid is the trans-isomer of butenedioic acid, while maleic acid is the cis-isomer. As a key intermediate in the tricarboxylic acid cycle (citric acid cycle), fumaric acid plays a crucial role in energy metabolism. It is produced from succinate via succinate dehydrogenase in the electron transport chain and is further converted to malate by fumarase. In addition to its role in energy metabolism, fumaric acid is also a product in the urea cycle.
Fumaric acid has significant importance in both biological systems and industrial applications. Since 1946, it has been used as a food acidulant and is approved as a food additive in the EU, USA, Australia, and New Zealand, designated as E297. It is commonly used in making wheat tortillas, food preservatives, and fermentation acids, especially in beverages and baking powders. Furthermore, fumaric acid has extensive applications in the pharmaceutical field. In the 1950s, it was developed in Germany as a treatment for psoriasis and marketed by Biogen Idec in Europe under the name Fumaderm. Dimethyl fumarate has been further developed as a treatment for multiple sclerosis. Additionally, fumaric acid is used in the production of polyester resins and polyols and as a mordant for dyes.
Given its multiple functions in biological systems and its wide industrial applications, accurately measuring the content of fumaric acid in biological samples is crucial for clinical diagnosis, disease monitoring, and industrial quality control.
Figure 1. Molecular Structure of Fumaric Acid
MtoZ Biolabs offers Fumaric Acid Analysis Service using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). This advanced method combines the separation capabilities of UPLC with the detection power of MS, ensuring high sensitivity and specificity in fumaric acid detection.
Analysis Workflow
Service Advantages
1. High Sensitivity and Precision
UPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of fumaric acid.
2. Rapid and Efficient
Optimized sample preparation and fast analysis ensure quick and efficient processing.
3. Wide Applicability
Suitable for various biological samples, including blood, urine, and tissues.
4. Accurate and Reliable Data
Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.
Sample Submission Requirements
Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.
Applications
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on Fumaric Acid
4. Raw Data
5. Custom Analysis Report
Our Fumaric Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.
How to order?
