GAP Analysis Service
- Highly Efficient Sample Recovery and Processing
- Accurate and Reliable Detection and Quantification
- Capability to Handle Various Sample Types
- Customized Data Analysis Services
- Rapid Service Response and Cost-Effectiveness
- Metabolic disorder-related disease studies
- Quantitative analysis of GAP
- Biomarker discovery and validation
- Drug development for energy metabolism
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
Glyceraldehyde-3-phosphate (GAP), also known as 3-phosphoglyceraldehyde, is a key intermediate in the glycolytic pathway and plays a vital role in cellular energy production and metabolism. Structurally, GAP is a three-carbon phosphorylated sugar aldehyde derived from fructose-1,6-bisphosphate during glycolysis. It serves as an important metabolite in both glycolysis and gluconeogenesis, where it is either oxidized to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase (GAPDH) or used in reverse metabolic processes, such as glucose synthesis.
Figure 1. The Structure of GAP
GAP is a critical molecule not only in energy metabolism but also in a variety of biochemical processes. It is directly involved in the production of ATP and NADH, which are essential for cellular energy balance and redox regulation. Furthermore, GAP serves as a precursor for the biosynthesis of key metabolites involved in pathways such as the pentose phosphate pathway, which generates reducing power (NADPH) and ribose-5-phosphate for nucleotide synthesis. Its central role in metabolism makes GAP an important focus in metabolic research, particularly in understanding the cellular response to metabolic stress, cancer metabolism, and metabolic diseases.
Recent research has shown that GAP and its associated enzymes, such as GAPDH, are involved in non-metabolic functions, including regulation of apoptosis, gene expression, and intracellular signaling. Aberrations in GAP metabolism and GAPDH activity have been linked to neurodegenerative disorders like Alzheimer's and Parkinson's diseases, as well as cancer. Understanding GAP metabolism and its broader biological roles is critical for advancing research in cellular metabolism, disease mechanisms, and potential therapeutic targets.
MtoZ Biolabs offers a state-of-the-art GAP Analysis Service, utilizing advanced mass spectrometry to provide accurate and detailed quantification of glyceraldehyde-3-phosphate in biological samples. Our service supports research in metabolic pathways, disease mechanisms, and cellular energy regulation, providing high-quality data for researchers aiming to explore the multifaceted roles of GAP in health and disease.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice.
Note: Please provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on GAP
4. Raw Data
5. Custom Analysis Report
MtoZ Biolabs is committed to providing the highest quality GAP analysis services. Contact us today to learn more about how we can help you.
How to order?
