Glyco-proteomics

Glycosylation is a common and complex post-translational modification, involving the covalent attachment of glycosyl groups to specific amino acids like asparagine, serine, or threonine on proteins. This modification plays a crucial role in protein folding, stability, solubility, and functionality. Glycosylation is essential in biological processes such as cell recognition, immune response, signal transduction, cell adhesion, and molecular transport. Abnormal glycosylation is linked to various diseases, including cancer, diabetes, neurodegenerative, and infectious diseases. Therefore, in-depth research on glycosylation and its functions is critical for understanding disease mechanisms and developing new therapies.

 



Reily, C. et al. Nat Rev Nephrol. 2019.

Figure 1. Major Types of Glycosylation in Humans

 

MtoZ Biolabs provides advanced glyco-proteomics services using advanced liquid chromatography-tandem mass spectrometry (LC-MS/MS). This technology systematically analyzes glycosylation sites and their dynamic changes, helping scientists understand the biological significance of glycosylation and its role in diseases.

 

Analysis Workflow

 



Bashir, H. et al. Protein Modificomics. 2019.

 

Service Advantages

 



 

Sample Submission Requirements

 



For detailed sample submission instructions, please consult our technical team.

 

Applications

Disease Mechanism Research: Discover disease-related glycosylation sites and proteins through glyco-proteomics analysis, aiding in disease mechanism research and new drug development.

 

Biomarker Discovery: Identify and validate glycosylation biomarkers for disease diagnosis and prognosis assessment.

 

Drug Development and Screening: Evaluate the impact of drugs on glycosylation, supporting drug development and target validation.

 

Immunology Research: Study the role of glycosylation in immune responses and cell recognition, revealing its regulatory mechanisms in the immune system.

 

Deliverables

1. Experimental Procedures

2. Relevant Mass Spectrometry Parameters

3. Detailed Information on Glycosylated Proteins

4. Mass Spectrometry Images

5. Raw Data