Histone Modifications

Histone modifications are a key aspect of epigenetics research, involving various covalent modifications of histones, such as methylation, acetylation, phosphorylation, and ubiquitination. These modifications regulate chromatin structure and gene expression by altering the interaction between histones and DNA or by recruiting specific protein complexes, thereby influencing gene activity. Histone modifications play critical roles in gene regulation, cell differentiation, development, and disease occurrence. For example, patterns of histone methylation and acetylation can indicate the activity state of genes, while abnormal histone modifications are often associated with cancer, neurodegenerative diseases, and immune disorders. Therefore, in-depth research on histone modifications is crucial for understanding gene regulation mechanisms, revealing disease mechanisms, and developing novel therapeutic strategies.

 

MtoZ Biolabs offers histone modification analysis services using high-resolution mass spectrometry (HR-MS). This technology comprehensively and accurately identifies and quantifies histone modifications, providing robust support for scientific research and drug development.

 

Analysis Workflow

 

 

Service Advantages

• High Sensitivity and Specificity: Utilize high-resolution mass spectrometers to ensure accurate identification and quantification of histone modifications.
• Comprehensive Histone Coverage: Detect and analyze various types of histone modifications, providing a comprehensive modification map.
• Dynamic Change Analysis: Monitor dynamic changes in histone modification states under different conditions, revealing regulatory mechanisms.
• Efficient Bioinformatics Analysis: Provide detailed information on modification sites and biological significance through professional data analysis platforms.

 

Sample Submission Requirements

 



For detailed sample submission instructions, please consult our technical team.

 

Applications

Gene Expression Regulation Research: Reveal the epigenetic mechanisms of gene expression regulation through histone modification analysis.

 

Cell Differentiation and Development: Study the role of histone modifications in cell differentiation and development, understanding their regulatory mechanisms.

 

Disease Mechanism Research: Discover disease-related histone modification abnormalities, aiding in disease mechanism research and new drug development.

 

Epigenetic Drug Development: Evaluate and optimize epigenetic drugs targeting histone modifications, supporting new drug development and target validation.

 

Deliverables

1. Experimental Procedures

2. Relevant Mass Spectrometry Parameters

3. Detailed Information on Histone Modifications

4. Mass Spectrometry Images

5. Raw Data