Homovanillic Acid Analysis Service

Homovanillic acid (HVA) is a major metabolite of dopamine metabolism, produced by the action of monoamine oxidase and catechol-O-methyltransferase. It is widely present in the urine and cerebrospinal fluid of humans and animals. As an important biomarker for nervous system function, measuring HVA levels is commonly used to assess central nervous system disorders such as Parkinson's disease and neuroblastoma. In psychiatry and neuroscience research, HVA levels are often used as markers of metabolic stress and are associated with dopamine levels in the brain. Studies have shown that the presence of HVA supports the diagnosis of neuroblastoma and malignant pheochromocytoma. Therefore, accurate quantitative and qualitative analysis of HVA is essential in clinical diagnostics, neuroscience research, and drug development.

 

Figure 1. Molecular Structure of Homovanillic Acid

 

MtoZ Biolabs offers Homovanillic Acid Analysis Service using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). This advanced method combines the separation capabilities of UPLC with the detection power of MS, ensuring high sensitivity and specificity in HVA detection.

 

Analysis Workflow

 



 

Service Advantages

• Rapid Analysis Cycle and Cost-Effectiveness
• Stable, Reliable, and Highly Sensitive Results
• Comprehensive One-Stop Service for Extensive Testing Needs
• User-Friendly Operation with Wide Application Scope
• Supported by Extensive Bioanalytical Resources and Advanced Platforms

 

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

 

Applications

• Assess central nervous system disorders such as Parkinson's disease, neuroblastoma, and malignant pheochromocytoma.
• Study the role and mechanisms of HVA in neuropsychiatric disorders such as depression and schizophrenia.
• Evaluate the impact of drugs on dopamine metabolism and related pathways.
• Analyze changes in HVA under different physiological and pathological conditions to explore its potential role in diseases.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Homovanillic Acid

4. Raw Data

5. Custom Analysis Report

 

Our Homovanillic Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.