Inactivated Vaccine Viral Inactivant Residue Testing

Inactivated vaccines refer to vaccines made by culturing and inactivating pathogenic microorganisms, which is a common type of vaccine. By inactivating the culture of bacteria, viruses or rickettsiae, it loses its pathogenicity to target organs, but retains the immunogenicity of the antigen, which can stimulate the immune system to produce an immune response, thereby achieving the purpose of preventing and treating diseases. For inactivated viral vaccines, the structural protein of the virus is one of the most important components of the vaccine, including surface proteins and capsid proteins. The structural protein of the virus is a key factor in the life cycle of the virus and the infection of the host by the virus, and it is also the main target of the vaccine-induced immune response. In the process of preparing inactivated vaccines, the inactivating agent is an essential part, which can ensure that the activity of the pathogen is completely eliminated, thereby ensuring the safety of the vaccine. Common inactivating agents include formaldehyde, chlorine dioxide, β-propiolactone, etc.

 

Although inactivating agents play a key role in vaccine preparation, their residues may pose potential safety issues, such as toxic or allergic reactions to the vaccine recipient. Therefore, it is very necessary to strictly detect the residual inactivating agents in the inactivated vaccine, which is also an important part of quality control in vaccine production. In this process, we need to use a variety of efficient, sensitive and accurate detection methods.

 

There are various methods to detect the residual inactivating agents in inactivated vaccines, including high performance liquid chromatography (HPLC), gas chromatography (GC), fluorescence spectroscopy, etc. For example, residual formaldehyde can usually be detected by HPLC or GC, while residual chlorine dioxide can be detected by fluorescence spectroscopy. These methods have high accuracy and sensitivity and can accurately quantify the residues of inactivating agents in complex vaccine samples.

 

MtoZ Biolabs provides you with a one-stop service for residual detection of virus inactivating agents in inactivated vaccines. Just tell us your experimental purpose and send the samples, and MtoZ Biolabs will be responsible for all subsequent projects, including sample processing, machine analysis, data analysis and project reports. Free consultation is welcome.