Infrared Spectral Analysis of Recombinant Protein Drugs

Recombinant protein drugs refer to protein products derived from animals and plants and developed through biotechnology research. They possess certain biological activity and can prevent, treat, and diagnose diseases in humans, animals, and plants. Compared to small molecule drugs, recombinant protein drugs have the advantages of high activity, high specificity, and low toxicity, making them favored by researchers. Currently, recombinant protein drugs are widely used in various fields such as tumors, autoimmune diseases, metabolic diseases, aging diseases, and degenerative diseases. Recombinant protein drugs are a type of large molecular complex compound, and understanding their structure is essential for understanding their function and stability.

 

Infrared spectroscopy is a common method for studying the structure of recombinant protein drugs. It uses the characteristics of substances absorbing, emitting, or scattering infrared radiation to obtain protein-related information. The application of infrared spectroscopy in the analysis of recombinant protein drugs is specifically reflected in: (1) Infrared spectroscopy can help determine the secondary structure of proteins, namely α-helices, β-folds, and random curls, etc.; (2) Amino acid residue analysis; (3) Monitoring protein conformational changes, such as the folding state of proteins, the impact of solvents and temperature on their structure, etc.; (4) Detection of protein denaturation states, such as partial or complete denaturation of proteins, the formation of protein aggregation states, etc.

 

MtoZ Biolabs provides one-stop recombinant protein drug infrared spectroscopy analysis services. This technology can macroscopically determine recombinant protein drugs in different states, different concentrations, and different environments, with fast detection speed and non-destructiveness.