L-Histidine Analysis Service
- Liquid Chromatography-Mass Spectrometry (LC-MS)
- Gas Chromatography-Mass Spectrometry (GC-MS)
- Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
L-Histidine is an essential amino acid crucial for protein synthesis, enzymatic reactions, immune function, and neurotransmission. It is converted into histamine by histidine decarboxylase, which serves as a key neurotransmitter and immune modulator, involved in inflammatory responses, allergic reactions, and gastric acid secretion. L-Histidine can also be converted into carnosine, a dipeptide with antioxidant and metal ion chelation properties. Accurate analysis of L-histidine and its metabolites is vital for understanding their roles and metabolic pathways in the body, as changes in their levels can indicate various health conditions, such as metabolic diseases, immune dysfunctions, and neurological disorders.
Figure 1. Molecular Structure of L-Histidine
MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of L-histidine and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of L-histidine in complex biological matrices.
Analysis Workflow
Experimental Instruments
Service Advantages
1. High Sensitivity and Precision
HPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of L-histidine and differentiating its isomers.
2. Rapid and Efficient
Optimized sample preparation and fast analysis ensure quick and efficient processing.
3. Wide Applicability
Suitable for various biological samples, including blood, urine, and tissues.
4. Accurate and Reliable Data
Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.
Sample Submission Requirements
Please ensure that the sample volume is greater than 0.2 g or 0.2 mL.
Applications
Clinical Research: Monitor L-histidine levels to study its roles in metabolic diseases, immune disorders, and neurological conditions.
Disease Monitoring: Analyze L-histidine and its metabolites to track the progression of liver disease, kidney disease, and cancer.
Nutritional Research: Assess L-histidine content in foods and supplements to guide nutritional intake and health management.
Drug Development: Investigate the potential applications of L-histidine and its metabolites in new drug development, evaluating efficacy and safety.
Sports Science: Study the role of L-histidine in athletic performance and recovery, optimizing training and nutrition strategies for athletes.
MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into L-histidine's extensive physiological roles through top-tier analytical techniques and expert services.
How to order?
