L-Methionine Analysis Service

L-methionine is an essential amino acid with crucial roles in protein synthesis, methylation reactions, and one-carbon metabolism. It serves as a key precursor in the methionine cycle, providing methyl groups necessary for DNA methylation, RNA transcription regulation, and protein function modulation. L-methionine is also vital for glutathione synthesis, an important cellular antioxidant. Given its central role in these physiological processes, precise analysis of L-methionine and its metabolites is essential for understanding its metabolic pathways and functions.

 



Figure 1. Molecular Structure of L-Methionine

 

MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of L-methionine and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of L-methionine in complex biological matrices.

 

Analysis Workflow

 

Service Advantages

 

Sample Submission Requirements

1. The samples should be free from any contaminants and precipitates.

 

2. Typically, non-pure powder samples should be provided in quantities of approximately 10 g, and liquid samples should be provided in volumes of no less than 10 mL.

 

3. For samples that are difficult to purify, the concentration should be greater than 200 µg/mL, with a volume of no less than 5 mL, or a solid mass of no less than 400 µg. Please note that the samples analyzed will not be returned; therefore, ensure to keep a backup of your samples.

 

Applications

Clinical Research: Monitor L-methionine levels to study its role in metabolic diseases (such as liver disease and cardiovascular diseases) and other health conditions, aiding diagnosis and treatment.

 

Nutritional Assessment: Analyze L-methionine content in foods and supplements to evaluate nutritional value and guide dietary intake and supplementation strategies.

 

Antioxidant Research: Assess the role of L-methionine in glutathione synthesis and its potential applications in antioxidant protection.

 

Drug Development: Explore the potential applications of L-methionine in new drug development, particularly for treating metabolic diseases and oxidative stress.

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into L-methionine's extensive physiological roles through top-tier analytical techniques and expert services.