Malonic Acid and its Derivatives Assay Service

Malonic acid is a crucial organic acid, widely present in various plants and microorganisms, and can also be produced in the human body through specific metabolic pathways. It plays an important role in biochemical reactions, especially in fatty acid synthesis. Abnormal levels of malonic acid may be associated with metabolic disorders, genetic diseases, and poisoning. Therefore, accurately measuring the content of malonic acid and its derivatives in biological samples is critical for clinical diagnosis, disease monitoring, and health assessment.

 

• Malonic Acid: A key intermediate in the malonic acid cycle, playing a significant role in energy metabolism. It is metabolized through specific enzyme-catalyzed reactions and may accumulate under pathological conditions, leading to metabolic disorders such as malonic aciduria.
• Diethyl Malonate: Produced by reacting malonic acid with ethanol, it is widely used in organic synthesis, particularly in pharmaceuticals and fragrances. Its structure allows it to serve as a crucial intermediate in various chemical reactions.
• Monoethyl Malonate: Produced by partially reacting malonic acid with ethanol, this derivative is important in chemical synthesis, commonly used to produce high-value chemicals and pharmaceuticals. It provides a flexible ester group in reactions, facilitating various organic transformations.
• Malonate Esters: Produced by reacting malonic acid with different alcohols, these compounds have diverse applications, including polymer synthesis and medicinal chemistry. These ester derivatives are significant in materials science and drug development.

 



Figure 1. Molecular Structure of Malonic Acid

 

MtoZ Biolabs offers Malonic Acid and its Derivatives Assay Service using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). This advanced method combines the separation capabilities of UPLC with the detection power of MS, ensuring high sensitivity and specificity in malonic acid and its derivatives detection.

 

Analysis Workflow

 



 

Service Advantages

• Rapid Analysis Cycle and Cost-Effectiveness
• Stable, Reliable, and Highly Sensitive Results
• Comprehensive One-Stop Service for Extensive Testing Needs
• User-Friendly Operation with Wide Application Scope
• Supported by Extensive Bioanalytical Resources and Advanced Platforms

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissue homogenates, and other biological samples.

 

2. Sample Volume

At least 200 μL of liquid sample or 200 mg of solid sample.

 

3. Sample Preservation

Store at -80°C to maintain stability.

 

Note: Provide details on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Malonic Acid and its Derivatives

4. Raw Data

5. Custom Analysis Report

 

Our Malonic Acid and its Derivatives Assay Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.