Methylmalonic Acid Analysis Service

Methylmalonic acid (MMA) is a crucial organic acid and an intermediate in vitamin B12 metabolism. The levels of MMA in the body serve as a biomarker for vitamin B12 deficiency, which is significant in diagnosing vitamin B12 deficiency and related conditions. Elevated MMA levels are associated with metabolic disorders such as methylmalonic acidemia, a genetic disorder that leads to the accumulation of MMA and severe health issues. Accurate analysis of MMA is essential for clinical diagnostics, metabolic research, and drug development.

 

Figure 1. Molecular Structure of Methylmalonic Acid

 

MtoZ Biolabs offers Methylmalonic Acid Analysis Service using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). This advanced method combines the separation capabilities of UPLC with the detection power of MS, ensuring high sensitivity and specificity in MMA detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity

Detects very low concentrations of MMA accurately.

 

2. High Specificity

Differentiates MMA from other compounds using mass spectrometry.

 

3. Rapid Analysis

Efficient sample preparation and fast detection processes for high-throughput analysis.

 

4. High Accuracy

Strict quality control ensures accuracy and reproducibility.

 

5. Versatility

Capable of analyzing MMA and its related metabolites.

 

Sample Submission Requirements

 



For detailed sample submission instructions, please consult our technical team.

 

Applications

1. Clinical Diagnostics: Diagnose vitamin B12 deficiency and methylmalonic acidemia by detecting MMA levels.

 

2. Metabolic Research: Study the role of MMA in energy metabolism and metabolic disorders.

 

3. Drug Development: Evaluate the impact of drugs on MMA metabolic pathways and identify potential therapeutic targets.

 

4. Nutritional Research: Assess vitamin B12 intake and metabolic status to guide dietary supplementation.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Methylmalonic Acid

4. Raw Data

5. Custom Analysis Report

 

Our Methylmalonic Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.