Morphine Analysis Service
- High Sensitivity and Accuracy: LC-MS technology can precisely identify and quantify trace components in complex samples.
- Broad Applicability: Suitable for various biological samples, including plant tissues, blood, and urine.
- Rapid Analysis: The process from sample handling to report generation is efficient, shortening the analysis cycle.
- Customized Services: Personalized analysis solutions provided based on specific customer needs.
- Tissue samples: ≥ 200 mg
- Plasma samples: ≥ 200 μL
- Blood samples: ≥ 200 μL
- Pharmaceuticals: ≥ 0.2 g
Morphine, an opioid analgesic, exerts its effect by binding to specific opioid receptors. It is predominantly metabolized in the liver, producing two primary metabolites: Morphine-3-glucuronide (M3G) and Morphine-6-glucuronide (M6G), which also undergo further transformation in the brain and kidneys. Morphine's capability to reduce cardiac preload and afterload makes it an effective therapeutic for acute left ventricular failure, enhancing cardiac performance. Moreover, its analgesic and sedative properties significantly reduce symptoms of anxiety, restlessness, and fear in patients. Morphine's pharmacological action includes an increase in smooth muscle tone within the gastrointestinal tract, bile ducts, and ureters, potentially leading to constipation as a side effect.
As a cornerstone of pain management, opioid medications like morphine are preferred for diverse pain conditions. Advances have led to the development of morphine derivatives such as Hydromorphone Hydrochloride, engineered to offer enhanced efficacy and minimized adverse effects, including reduced metabolite accumulation without immune suppression.
Figure 1. Molecular Structure of Morphine
MtoZ Biolabs utilizes liquid chromatography-mass spectrometry (LC-MS) for metabolomic analysis of morphine. This technique combines the high separation efficiency of high-performance liquid chromatography (HPLC) with the high sensitivity of mass spectrometry (MS), allowing for the precise detection and quantification of trace components in complex samples. Our services extend beyond identification and quantification to include in-depth studies on the structure-activity relationships, metabolic pathways, and biological activity of alkaloids, providing comprehensive data support.
Analysis Workflow
Services at MtoZ Biolabs
Service Advantages
Sample Submission Requirements
For detailed sample submission instructions, please consult our technical team.
Applications
Clinical Pharmacokinetic Monitoring
Substance Abuse Monitoring
Pharmacovigilance
Pharmacodynamic Studies
At MtoZ Biolabs, we are dedicated to offering superior metabolomic analysis services for morphine, aimed at enhancing your understanding of its biological functions and assisting in the development and regulatory compliance of associated products. We are eager to support your research endeavors as a trusted scientific partner.
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