MtoZ Biolabs Comprehensive Metabolomics Solutions: Powerful Support for Multi-Disciplinary Research

Metabolomics focuses on the identification and quantification of all metabolites in a biological sample, integrating chemical information to understand complex biological systems. It is an essential tool for studying metabolic pathways, disease mechanisms, drug discovery, and more. The convergence of mass spectrometry with metabolomics allows for the comprehensive profiling of metabolites, offering insights into cellular functions and metabolic responses.

 

At MtoZ Biolabs, we provide comprehensive metabolomics solutions to meet the evolving needs of biological research. Metabolomics is the study of the small molecules (metabolites) present within cells, tissues, or organisms. By analyzing these metabolites, our metabolomics services offer valuable insights into biological processes, disease states, and the effects of various treatments.

 

Applications

Our metabolomics services cover a broad range of applications, including:

 



 

Research Methods

MtoZ Biolabs employs several metabolomics methodologies to support your research goals:

✅ Untargeted Metabolomics

A broad-spectrum approach aimed at identifying all detectable metabolites without bias. We utilize advanced techniques such as LC-MS/MS, GC-MS, and NMR to profile the metabolome extensively. This method is particularly suited for discovering unknown metabolites and generating hypotheses.

 

✅ Quasi-Targeted Metabolomics

A hybrid approach combining untargeted and targeted methods, offering a balance between comprehensive profiling and precise quantification. This technique targets a predefined set of metabolites while remaining open to the detection of unknowns.

 

✅ Targeted Metabolomics

A precise method focused on the quantification of known metabolites, using Multiple Reaction Monitoring (MRM) with robust standards. This method is essential for validating biomarkers and conducting detailed pathway analyses.

 

Untargeted Metabolomics Overview

Untargeted metabolomics is a non-biased approach aimed at detecting as many metabolites as possible within a sample. Through advanced mass spectrometry technologies such as LC-MS/MS, our untargeted metabolomics workflow provides a comprehensive view of the metabolite profile, enabling the discovery of novel biomarkers and pathways.

 



 

Quasi-Targeted Metabolomics

Our quasi-targeted metabolomics service combines the comprehensive nature of untargeted analysis with the precision of targeted methods. This approach allows researchers to focus on specific metabolic pathways while still capturing unexpected findings.

 



 

Targeted Metabolomics Overview

Targeted metabolomics offers precise and reliable quantification of specific metabolites, critical for verifying hypotheses and investigating known metabolic pathways. Our experts use advanced MRM and PRM techniques to deliver targeted metabolomics solutions that ensure accuracy and reproducibility.

 



 

Lipidomics Solutions

Lipidomics, a branch of metabolomics, focuses on the comprehensive analysis of lipids in biological samples. Our lipidomics platform, based on LC-MS/MS, investigates the composition and dynamics of lipids in various biological systems. Lipids play crucial roles in energy storage, signaling, and cellular structure, making lipidomics essential for studying metabolic disorders, inflammation, and cancer.

 

Lipid-Involved Biological Processes

Lipids play a fundamental role in many biological processes. First, they are essential components of cell membranes, contributing to membrane stability and fluidity, and playing a key role in signal transduction. Lipids also serve as energy storage molecules, participating in energy metabolism by providing energy through fatty acid oxidation. Furthermore, lipids are crucial in cellular signaling, with specific lipid molecules (such as phospholipids and sphingolipids) acting as signaling mediators to regulate processes like cell growth, differentiation, and apoptosis.

 

Abnormal lipid metabolism is linked to several diseases. For instance, abnormal lipid metabolism can lead to fat deposition and atherosclerosis, increasing the risk of cardiovascular diseases. In the endocrine system, lipid metabolism disorders are associated with metabolic diseases such as diabetes and obesity. In the nervous system, lipids maintain neuronal functions, and their dysregulation may contribute to neurodegenerative diseases like Alzheimer's disease. Moreover, lipid metabolism plays a critical role in cancer development, as altered lipid metabolic pathways in many cancer cells promote tumor growth and metastasis.

 



 

Lipidomics Workflow



 

MtoZ Biolabs is dedicated to providing advanced metabolomics and lipidomics solutions tailored to your research needs. Our expert team, cutting-edge technology, and deep understanding of multi-omics ensure that we deliver high-quality, reliable data for your studies. By leveraging our services, researchers can gain comprehensive insights into metabolic processes and contribute to groundbreaking discoveries in various fields of science. Let us help you explore the metabolome and uncover new dimensions in your research.