MtoZ Biolabs: Deep Blood 4D-DIA Proteomics Service

Blood is a vital biological fluid, easily accessible and frequently collected in clinical settings. Its comprehensive role in reflecting physiological conditions makes it a key source for studying disease biomarkers, physiological states, and overall biological function. Blood samples hold immense potential in biomarker discovery due to their non-invasive nature and the vast range of molecules they contain.

 

Challenges in Blood Sample Proteomics

Blood proteomics research, while promising, presents several critical challenges:

❗❗❗ Dynamic Range Complexity: The protein abundance range in blood spans over 10 orders of magnitude, making detection of low-abundance proteins (e.g., albumin at ~50 mg/mL and interleukin-6 at ~5 pg/mL) extremely difficult.

 

❗❗❗ Extreme Protein Distribution Skew: High-abundance proteins constitute over 99% of the total protein content, leaving low-abundance proteins comprising less than 1%, which are often the most relevant for biomarker discovery.

 

❗❗❗ Matrix Effect and Interference: The presence of proteins with widely varying concentrations affects the detection of lower-abundance proteins, creating technical limitations in accurate protein quantification.

 

Deep Blood 4D-DIA Proteomics: A Revolutionary Solution

MtoZ Biolabs introduces Deep Blood 4D-DIA (Data-Independent Acquisition) Proteomics, an advanced technology built to overcome the inherent challenges in blood proteomics research. By integrating the power of 4D-DIA and nanomagnetic bead-based enrichment techniques, we provide deep and precise analysis of blood samples, especially targeting low-abundance proteins. This approach enables comprehensive proteomic profiling, unlocking new insights into disease pathways and biomarker discovery.

 

Key Features of Deep Blood 4D-DIA Proteomics:

✅ Comprehensive Protein Coverage: We employ nanoparticle magnetic bead enrichment and selective adsorption to capture both medium- and low-abundance proteins.

✅ High Sensitivity: Our platform delivers the ability to identify up to 1,500-2,000+ proteins, ensuring a deep proteomic analysis.

✅ Advanced Instrumentation and Software: We leverage the cutting-edge timsTOF Pro2 and Spectronaut software platforms for high-resolution protein identification and quantification, with upgraded algorithms ensuring optimized results.

 



 

Five-Dimensional Solutions in Blood Proteomics

To tackle the complexity of blood proteomics, we offer a multi-pronged approach that includes:

1. Deep 4D-DIA Proteomics

Provides high accuracy and sensitivity for medium- and low-abundance proteins, supporting deep insights into biological systems.

 

2. Large-Scale Targeted Proteomics

Suitable for high-precision analysis with extensive data coverage, powered by advanced DIA techniques.

 

3. Complete Proteome and Glycome Analysis

Delivers holistic protein and sugar-modification profiles with integrated workflows.

 

4. Exosomal Protein Proteomics

Focused on proteins associated with exosomes, offering critical insights into extracellular vesicle biology.

 

5. Targeted Olink Proteomics

Utilizing advanced proximity extension assays (PEA) to deliver ultra-sensitive measurements across multiple disease-related proteins.

 

Sample Delivery Guidelines

To ensure the highest quality analysis, we recommend the following sample collection and storage guidelines:

 



 

Why Choose MtoZ Biolabs?

MtoZ Biolabs' Deep Blood 4D-DIA Proteomics Service represents a new frontier in proteomic analysis. Our ability to profile large numbers of proteins at high sensitivity, coupled with advanced bioinformatics platforms, offers unparalleled insights into biological processes and disease mechanisms. By choosing our service, you gain access to comprehensive solutions for biomarker discovery, clinical research, and translational science.

 

For more information, please visit our website or contact us to discuss how our Deep Blood 4D-DIA Proteomics can accelerate your research.