N-Acetylaspartate Analysis Service

N-Acetylaspartate (NAA) is a crucial neural metabolite primarily found in neurons and widely distributed throughout the brain. It is the second most abundant molecule in the brain after glutamate. NAA is located in neurons, oligodendrocytes, and myelin, and is synthesized in mitochondria from aspartate and acetyl-CoA. It plays a vital role in brain metabolism, neural signal transmission, and brain development, serving as a marker of neuronal health and facilitating metabolic cooperation between glial cells and neurons.

 

Changes in NAA levels are linked to various neurological disorders, including Alzheimer's disease, epilepsy, brain injury, schizophrenia, and multiple sclerosis. Precise analysis of NAA content and metabolism provides critical insights into its mechanisms in the nervous system, offering valuable data for the diagnosis, treatment, and prognosis of related diseases.

 

 

Figure 1. Molecular Structure of NAA

 

MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of NAA and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of NAA in complex biological matrices.

 

Analysis Workflow

 

 

 

Service Advantages

 

 

 

Sample Submission Requirements

 

 

For detailed sample submission instructions, please consult our technical team.

 

Applications

Neurological Disease Research: Analyze NAA level changes to study its role in neurological disorders such as Alzheimer's disease and epilepsy.

 

Brain Development Research: Study the role of NAA in brain development by analyzing its level changes at different developmental stages.

 

Drug Development: Assess the impact of new drugs on NAA metabolism to support the development and evaluation of drugs for neurological disorders.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on NAA and Their Metabolites

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into NAA's extensive physiological roles through top-tier analytical techniques and expert services.