N-Acetylneuraminic Acid Analysis Service

N-acetylneuraminic acid (Neu5Ac) is a crucial sialic acid widely present in glycoproteins and glycolipids on vertebrate cell surfaces. It plays key roles in cell recognition, signal transduction, immune response, pathogen infection, and tumor metastasis, making it essential in neurobiology, immunology, and infectious disease research.

 

Changes in Neu5Ac levels are linked to various diseases. In cancer, elevated Neu5Ac on tumor cells promotes invasion and metastasis. In cardiovascular diseases, Neu5Ac modifies low-density lipoprotein, influencing atherosclerosis development. Neu5Ac metabolism is also studied in neurodegenerative diseases like Alzheimer's, where its level changes may serve as biomarkers.

 

Neu5Ac is critical in pathogen infection processes. Many pathogens, such as influenza viruses and certain bacteria, bind to Neu5Ac on host cells to mediate infection. Thus, Neu5Ac analysis is vital in infectious disease research and vaccine development.

 

Given its role in physiological and pathological processes, analyzing Neu5Ac is scientifically and clinically valuable. Accurate Neu5Ac analysis provides insights for disease prevention, diagnosis, and treatment.

 

 

Figure 1. Molecular Structure of N-Acetylneuraminic Acid

 

MtoZ Biolabs offers N-Acetylneuraminic Acid Analysis Service using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of Neu5Ac in complex biological matrices.

 

Analysis Workflow

 



 

Service Advantages

 



 

Sample Submission Requirements

Please ensure that the sample volume is greater than 0.2 g or 0.2 mL.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Neu5Ac

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into Neu5Ac's extensive physiological roles through top-tier analytical techniques and expert services.