N-Propionylglycine Analysis Service

N-Propionylglycine is a significant metabolic product formed by the combination of propionate and glycine, primarily metabolized in the liver. The accumulation of N-Propionylglycine can indicate metabolic abnormalities and is linked to several genetic metabolic diseases, such as propionic acidemia and methylmalonic acidemia. These conditions typically arise from specific enzyme deficiencies, leading to disrupted propionate metabolism and subsequent accumulation of N-Propionylglycine. Therefore, analyzing N-Propionylglycine levels is crucial for understanding its role and metabolic pathways in disease conditions.

 

 

Figure 1. Molecular Structure of N-Propionylglycine

 

MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of N-Propionylglycine. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of N-Propionylglycine in complex biological matrice

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity and Precision

LC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of N-Propionylglycine.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

 



For detailed sample submission instructions, please consult our technical team.

 

Applications

Metabolic Disease Research: Studying the role of N-Propionylglycine in propionic acidemia and other metabolic diseases.

 

Drug Development: Assessing the impact of drugs on N-Propionylglycine metabolism and screening potential therapeutic agents.

 

Nutritional Metabolism Research: Studying the regulatory effects of diet and nutritional supplements on N-Propionylglycine levels.

 

Clinical Diagnosis: Assisting in the diagnosis of related metabolic diseases by detecting N-Propionylglycine levels.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on N-Propionylglycine

4. Raw Data

5. Custom Analysis Report

 

For more details about our services or any inquiries, please contact our expert team. We look forward to collaborating with you to advance scientific research and technology.