N2,N2-dimethylguanosine Analysis Service
- Extensive expertise in handling various biological samples and extracting metabolites.
- State-of-the-art mass spectrometry platforms.
- Strict quality control to ensure reliable results.
- Comprehensive statistical and bioinformatics analysis.
- Personalized service to meet various research needs.
- Biomarker discovery
- Drug development
- Biochemical research
- Disease diagnosis
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
N2,N2-dimethylguanosine (m2,2G) is a primary degradation product of tRNA. Structurally, it is a guanosine that carries two additional methyl groups on the nitrogen atom at the 2-position. It is involved in several metabolic pathways, including purine metabolism and RNA degradation. N2,N2-dimethylguanosine plays a crucial role in the modification of RNA, optimization of protein synthesis, and maintaining stability of tRNA structure.
N2,N2-dimethylguanosine is a key indicator of RNA methylation status, a critical modification associated with gene expression regulation, RNA stability, and stress response. Its dysregulation has been linked with a variety of diseases, including cancer and neurological disorders. Therefore, the accurate detection and quantification of N2,N2-dimethylguanosine are essential for understanding its biological function and application in disease diagnosis and therapeutics.
Figure 1. The Structure of N2,N2-dimethylguanosine
MtoZ Biolabs offers a comprehensive N2,N2-dimethylguanosine Analysis Service using advanced mass spectrometry technologies. Our service provides accurate and sensitive quantification of m2,2G in diverse biological samples, enabling researchers to explore the significance of this RNA modification in gene expression regulation and disease development.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice.
Note: Please provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on N2,N2-dimethylguanosine
4. Raw Data
5. Custom Analysis Report
For more information, please contact our customer service. MtoZ Biolabs is ready to deliver top-notch services to meet your research needs.
How to order?
