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    O-Phospho-L-Serine Analysis Service

      O-Phospho-L-Serine (O-PLS) is a crucial amino acid derivative involved in cellular signal transduction and metabolic regulation. O-PLS plays an essential role in phosphorylation processes and serves as a key intermediate in protein phosphorylation. By participating in the regulation of kinases and phosphatases, O-PLS influences biological processes such as cell proliferation, differentiation, and apoptosis. Variations in O-PLS levels can be linked to conditions such as neurodegenerative diseases, metabolic disorders, and cancer. Accurate measurement of O-PLS concentrations provides insights into its biological roles, aiding in the diagnosis and treatment of related conditions.

       

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      Figure 1. Molecular Structure of O-PLS

       

      MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of O-PLS and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of O-PLS in complex biological matrices.

       

      Analysis Workflow

       

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      Experimental Instruments

      • Liquid Chromatography-Mass Spectrometry (LC-MS)
      • Gas Chromatography-Mass Spectrometry (GC-MS)
      • Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

       

      Service Advantages

       

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      Sample Submission Requirements

      Please ensure that the sample volume is greater than 0.2 g or 0.2 mL.

       

      Applications

      Neuroscience Research: Study the roles of O-PLS in neurotransmitter metabolism and neurodegenerative diseases, exploring new therapeutic avenues.

       

      Metabolic Research: Investigate the roles of O-PLS in cellular signal transduction and metabolic regulation.

       

      Drug Development: Evaluate the impact of drugs on O-PLS metabolism to aid in developing new therapeutic agents.

       

      Cancer Research: Analyze the metabolic changes of O-PLS in tumor cells, exploring new diagnostic and therapeutic methods.

       

      Deliverables

      1. Experimental Procedures

      2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

      3. Detailed Information on O-PLS and their Metabolites

      4. Raw Data

      5. Custom Analysis Report

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