Organic Acids Analysis Service

Organic acids are critical intermediates in metabolic processes, present in animals, plants, microorganisms, and humans. They are essential for energy metabolism, acid-base balance, detoxification, and signal transduction. Abnormal levels of organic acids are linked to various conditions, including metabolic disorders, genetic diseases, nutritional imbalances, and poisoning. Accurate measurement of organic acids in biological samples is vital for clinical diagnosis, disease monitoring, and health assessment.

 

Figure 1. Sources of Organic Acids

 

MtoZ Biolabs offers Organic Acids Analysis Service using both ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and gas chromatography-mass spectrometry (GC-MS). These advanced methods combine the separation capabilities of UPLC and GC with the detection power of MS, ensuring high sensitivity and specificity in organic acids detection. UPLC-MS is ideal for non-volatile and thermally unstable acids, while GC-MS excels in analyzing volatile, low molecular weight acids. By integrating both methods, we provide a versatile and comprehensive solution for diverse research and clinical requirements.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity and Precision

LC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of organic acids.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

1. Sample Types and Volume



 

2. Sample Transportation

For shipping, it is recommended to use an adequate amount of dry ice, considering that 3-4 kg of dry ice sublimates in one day. It is advisable to use larger blocks of dry ice as they sublimate more slowly. Ensure samples are sealed in a foam box and opt for the fastest possible shipping method to minimize sample degradation during transport.

 

Applications

1. Clinical Diagnosis: Measure organic acid levels in patients to assist in diagnosing metabolic disorders, genetic diseases, and poisoning.

 

2. Disease Monitoring: Monitor changes in organic acid levels to assess disease progression and treatment efficacy.

 

3. Nutritional Research: Analyze the content of organic acids in food and nutritional supplements to guide dietary intake and supplementation strategies.

 

4. Environmental Monitoring: Detect organic acid pollution in environmental samples to assess ecosystem health.

 

5. Basic Biological Research: Study the roles of organic acids in metabolic pathways to gain deeper insights into their biological functions and mechanisms.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Organic Acids

4. Raw Data

5. Custom Analysis Report

 

Our Organic Acids Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.