Oxypurinol Analysis Service

    Oxypurinol is a pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6, with a molecular formula of C₅H₄N₄O₂ and a molecular weight of 152.11 g/mol. Oxypurinol is the primary active metabolite of allopurinol, directly involved in inhibiting xanthine oxidase (XO), thereby reducing uric acid production. Accurate quantification of oxypurinol and its metabolites in serum and urine is essential for evaluating the therapeutic efficacy of allopurinol and optimizing management strategies for gout and hyperuricemia. By quantitatively analyzing oxypurinol, healthcare professionals can determine whether a patient has achieved effective uric acid control and adjust treatment plans accordingly.

     

    Moreover, analyzing the levels of oxypurinol and its metabolites helps to understand the absorption, metabolism, and excretion of allopurinol in patients. These data are critical for assessing drug efficacy and detecting potential toxic reactions, especially in patients who exhibit adverse reactions or insufficient therapeutic response. Additionally, this analysis can help identify patients with abnormal metabolic capacity, such as those with impaired liver function or metabolic disorders caused by drug interactions.

     

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    Figure 1. The Structure of Oxypurinol

     

    MtoZ Biolabs offers a progressive Oxypurinol Analysis Service, backed by our sophisticated liquid chromatography-mass spectrometry (LC-MS) platform and a team of metabolomics experts. We provide an extensive analysis of oxypurinol, delivering high sensitivity and precision.

     

    Analysis Workflow 

     

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    Service Advantages

    • Extensive expertise in handling various biological samples and extracting metabolites.
    • State-of-the-art mass spectrometry platforms.
    • Strict quality control to ensure reliable results.
    • Comprehensive statistical and bioinformatics analysis.
    • Personalized service to meet various research needs.

     

    Applications

    • Improving disease diagnosis
    • Accelerating the discovery of innovative therapeutics
    • Finding new disease biomarkers
    • Unraveling new insights into disease mechanisms

     

    Sample Submission Requirements

    1. Sample Types

    Serum, plasma, urine, tissues, and other biological samples. It is recommended to choose more than 3 materials with the same condition for each sample.

     

    2. Sample Volume

    • Animal tissue ≥ 100 mg
    • Plant tissue ≥ 200 mg
    • Serum/ Plasma ≥ 200 μL
    • Urine ≥ 2 mL

     

    3. Sample Preservation

    Store at -80°C to ensure stability.

     

    Note: Please provide details on sample collection and handling.

     

    Deliverables

    1. Experimental Procedures

    2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

    3. Detailed Information on Oxypurinol

    4. Raw Data

    5. Custom Analysis Report

     

    Our oxypurinol analysis service aims to expedite your research and product development processes by delivering precise and trustworthy results. If you have any questions or would like to learn more about our analysis services, please feel free to contact us. We look forward to collaborating with you to advance scientific research and clinical applications.

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