Procyanidin C1 Analysis Service
- High-Performance Liquid Chromatography (HPLC): For separating and quantifying different types of proanthocyanidins.
- Mass Spectrometry (MS): Combined with HPLC to provide molecular weight and structural information of proanthocyanidins.
- Nuclear Magnetic Resonance (NMR): For detailed molecular structure analysis of proanthocyanidins.
- Spectroscopy (e.g., UV-Vis and FTIR): For preliminary identification and quantitative analysis.
Polyphenols are the largest group of secondary metabolites in plants, and their structural determination has been a focal point in research. Among polyphenols, procyanidin, also known as condensed tannins, are derived from proanthocyanidins. Procyanidin and proanthocyanidins are ubiquitously present in the plant kingdom and are commonly found in varying concentrations in everyday foods such as fruits, vegetables, legumes, grains, and nuts, as well as in cosmetics and pharmaceuticals containing plant materials. As natural antioxidants, procyanidins are used to stabilize food color, prevent rancidity caused by the oxidation of unsaturated fats, and for the chemoprevention of various degenerative tumors. Besides their antioxidant properties, procyanidin have reported anticancer, anti-infection, anti-inflammatory, cardioprotective, antibacterial, antimutagenic, wound healing, antidiabetic, and antiallergic activities.
Procyanidin C1 is a trimer made up of three catechin units connected via C-type bonds (C4-C8 or C4-C6). It is commonly found in grape seeds, apples, and cocoa. This compound has potent antioxidative, anti-inflammatory, anticancer, and antiviral properties. Procyanidin C1 is widely applied in nutritional supplements, food additives, and pharmaceuticals, especially for its anti-aging and skin-protective benefits.
Figure 1. The Structure of Procyanidin C1
Services at MtoZ Biolabs
1. Detectable Procyanidins at MtoZ Biolabs
2. Procyanidins Analysis Techniques
3. Procyanidin C1 Targeted Metabolomics Analysis
Figure 2. The Workflow of Targeted Metabolomics for Procyanidin C1
Applications
1. Inhibiting Tumor Growth and Metastasis in Colon Cancer
Lv, JL. et al. J Adv Res. 2024.
2. Inhibiting Bleomycin-induced Pulmonary Fibrosis
Shao, M. et al. FASEB J. 2024.
Proanthocyanidins, oligomeric compounds composed of catechin and epicatechin monomers, are widely present in food and hold significant medicinal value. Utilizing the LC-MS technology platform, MtoZ Biolabs provides qualitative and quantitative analysis of procyanidin C1 with exceptional sensitivity, reproducibility, and accuracy, expanding the research on its biological activities and medicinal value.
Deliverables
1. Experimental Procedures
2. Relevant Mass Spectrometry Parameters
3. Detailed Information on Procyanidin C1 Analysis
4. Mass Spectrometry Images
5. Raw Data
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