Protein Arginine Methylation Analysis
- Investigating disease mechanisms
- Discovering new drug targets
- Researching gene expression and signaling pathways
- Conducting epigenetic studies
Protein arginine methylation is a crucial post-translational modification, catalyzed by protein arginine methyltransferases (PRMTs), which transfer methyl groups to arginine residues on proteins. This modification exists in three forms: monomethylation, asymmetric dimethylation, and symmetric dimethylation. It plays a pivotal role in key biological processes such as gene regulation, RNA metabolism, signal transduction, and DNA repair, particularly in diseases like cancer, autoimmune disorders, and neurological conditions.
Figure 1. Arginine Methylation
As an excellent provider of mass spectrometry analysis services, MtoZ Biolabs leverages advanced high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) platforms to provide precise and sensitive protein arginine methylation analysis. Our services not only identify methylation sites with high accuracy but also offer quantitative insights, enabling researchers to deeply explore the biological relevance of these modifications.
Analysis Workflow
Services at MtoZ Biolabs
MtoZ Biolabs offers two levels of arginine methylation analysis: target protein-specific and proteome-wide. Our target protein arginine methylation analysis is focused on detecting methylation modifications on specific proteins, using immuno-enrichment and high-resolution mass spectrometry to precisely identify methylation sites on arginine residues. This helps uncover the role of these modifications in specific biological pathways. For broader applications, our arginine methylation proteomics employs high-throughput mass spectrometry to comprehensively profile methylation across the proteome, providing a systemic overview of modification patterns and their biological significance.
Service Advantages
1. Advance Analysis Platform
MtoZ Biolabs established an advanced protein PTM analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality
Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate PTM proteomics analysis data providing clients with a comprehensive data report.
4. Wide Applicability
Suitable for various biological samples, including blood, urine, and tissues.
5. Customized Service
Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.
Sample Submission Requirements
For more sample details, please consult our technical team.
Applications
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
Beyond arginine methylation, MtoZ Biolabs also offers comprehensive analysis services for other PTMs such as phosphorylation, ubiquitination, and acetylation. Leveraging our cutting-edge mass spectrometry technology, we support researchers in unraveling the roles of these modifications in areas such as signal transduction, protein degradation, and gene regulation, advancing both basic biological research and disease-related studies. Contact us to discuss a customized analysis solution tailored to your research needs.
How to order?
