Protein Symmetric Dimethylation Analysis

Protein symmetric dimethylation is a key form of post-translational modification (PTM) that typically occurs on lysine (Lys) or arginine (Arg) residues. In symmetric dimethylation, two methyl groups are attached to the nitrogen atoms of the guanidinium group in arginine. This modification is crucial for regulating gene expression, chromatin remodeling, and signal transduction. It significantly impacts biological processes such as cell differentiation, immune response, and cancer progression. Compared to asymmetric dimethylation, symmetric dimethylation is more closely associated with gene silencing and chromatin condensation, making it a primary focus in the study of epigenetic regulation.

 

 

Figure 1. Arginine Symmetric Dimethylation

 

MtoZ Biolabs, utilizing its advanced mass spectrometry platform, provides comprehensive and accurate Protein Symmetric Dimethylation Analysis services. Through high-resolution mass spectrometry and targeted enrichment strategies, we support researchers in uncovering the roles of symmetric dimethylation in gene regulation, signaling pathways, and disease mechanisms.

 

Analysis Workflow



 

Services at MtoZ Biolabs

MtoZ Biolabs offers comprehensive protein symmetric dimethylation analysis services at both the target protein and proteomics levels. Our target protein symmetric dimethylation analysis employs immunoprecipitation combined with mass spectrometry to accurately detect modifications on specific proteins, making it ideal for investigating their roles in gene regulation and signal transduction pathways. For broader applications, our symmetric dimethylation proteomics utilizes high-throughput mass spectrometry to systematically examine the entire proteome, uncovering modification patterns that are essential for research in epigenetics and cancer. This approach supports the identification of potential biomarkers and underlying regulatory mechanisms.

 

Service Advantages

Why Choose MtoZ Biolabs?

1. Advance Analysis Platform: MtoZ Biolabs established an advanced protein PTM analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate PTM proteomics analysis data providing clients with a comprehensive data report.

4. Comprehensive Coverage: We offer quantitative analysis of symmetric dimethylation across multiple proteins, delivering a detailed modification landscape.

5. Customized Service: We provide flexible and tailored experimental designs to meet specific research needs, offering a personalized approach to analysis.

 

Sample Submission Requirements

 

 

For more sample details, please consult our technical team.

 

Applications

• Gene Expression and Chromatin Regulation
• Disease Mechanism Research
• Cell Signaling Pathways
• Drug Development

 

Deliverables

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)

4. Data Analysis, Preprocessing, and Estimation (project-dependent)

5. Bioinformatics Analysis

6. Raw Data Files

 

With our advanced mass spectrometry platform and expertise, MtoZ Biolabs offers precise Protein Symmetric Dimethylation Analysis for accurate detection and quantification. We also provide services for other methylation modifications, including monomethylation, asymmetric dimethylation, trimethylation, and additional PTMs such as propionylation, acetylation, and phosphorylation. We are committed to delivering comprehensive technical support to advance your research. Please contact us for more details.