Resources
Proteomics Databases
Metabolomics Databases
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• Post-Translational Modification Analysis
Post-translational modification analysis is pivotal in studying the various chemical modifications proteins undergo after their synthesis. These modifications occur through enzymatic processes and include phosphorylation, acetylation, methylation, and ubiquitination, among others, each playing critical roles in modulating protein function, structure, and cellular localization. Post-translational modification analysis extends beyond basic biological research, finding applications in disease diagnosis, ......
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iTRAQ labeling (Isobaric Tags for Relative and Absolute Quantitation) employs isotopic tags to facilitate the simultaneous quantitation of up to eight proteomic samples. By chemically tagging peptides, this method allows for precise quantification of protein abundance using mass spectrometry. iTRAQ's high quantification efficiency makes it especially valuable in biomedical research, including the investigation of complex biological systems and disease mechanisms. Its applications span the discovery of......
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Proteomic analysis service provides a comprehensive study of protein composition, structure, and function at a large scale, assisting researchers, medical institutions, and businesses in understanding proteomic data from biological samples. Focused on the holistic analysis of proteins within cells or tissues under specific conditions, proteomics enables insights into protein roles across biological processes, unveiling disease mechanisms, developing therapeutic strategies, and discovering biomarkers. ......
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DDA proteomics is a widely utilized mass spectrometry technique in proteomics research. It selectively analyzes peptides within a sample to identify and quantify proteins. The fundamental principle of DDA proteomics involves the mass spectrometer scanning target samples and acquiring data in a data-dependent mode. This method can identify and characterize numerous proteins in a single experiment, providing crucial insights into dynamic changes within biological systems. DDA proteomics is instrumental ......
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• Monoclonal Antibody Structure Characterization
Monoclonal antibody structure characterization involves the detailed analysis of molecular structures, conformations, disulfide bond sequences, and glycosylation of monoclonal antibodies through a variety of techniques. These antibodies, produced by a single B cell clone, exhibit high specificity and affinity. Characterization encompasses primary and higher-order structures, as well as protein heterogeneity. This process ensures the structural integrity and functional activity of antibodies and serves......
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Peptide LC-MS analysis is a technique that integrates liquid chromatography (LC) and mass spectrometry (MS) for proteomics research. This method enables the separation of complex peptide mixtures and the precise detection and identification of these peptides using a mass spectrometer, supporting both qualitative and quantitative protein analyses. The LC component separates peptides in complex samples, while the MS component detects these peptides by their mass-to-charge ratio (m/z) and generates mass ......
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• In Silico Characterization of Protein
In silico characterization of protein is a method that employs bioinformatics and computational techniques to thoroughly analyze proteins in terms of their sequences, structures, and functions. Proteins are fundamental components of biological processes, responsible for metabolic regulation, signal transduction, and molecular transport. Although traditional experimental techniques like X-ray crystallography and nuclear magnetic resonance (NMR) provide detailed insights into protein structures and func......
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• MALDI-TOF Protein Sequencing
MALDI-TOF protein sequencing is a pivotal technique for determining protein amino acid sequences. This method involves combining samples with a matrix, then utilizing laser exposure to ionize proteins. These ions are analyzed by time-of-flight mass spectrometry to measure their mass-to-charge ratios. The variation in flight times provides mass data, enabling inference of amino acid composition and sequences. MALDI-TOF protein sequencing is extensively applied in proteomics for tasks such as protein id......
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Homology sequence analysis is a widely used method in molecular biology that elucidates evolutionary relationships and potential functions by comparing sequence similarities across different organisms or within the genome of a single organism. "Homologous sequences" refer to gene or protein sequences that have been inherited from a common ancestor. In molecular biology research, homology sequence analysis is a fundamental technique, crucial not only for understanding gene function but also for explori......
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Histone mass spectrometry is a sophisticated technique that utilizes contemporary mass spectrometry to investigate histones and their post-translational modifications. These histones are fundamental to chromatin architecture, influencing gene expression and chromatin dynamics through nucleosome formation with DNA. This method's high sensitivity and throughput enable precise detection of histone sequences and their modification states, offering substantial data support for studies in epigenetics, disea......
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