Resources
Proteomics Databases
Metabolomics Databases
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• Mass Spectrometry Quantification
Mass spectrometry quantification is a widely used technique for protein quantification in biological samples. It provides both relative and absolute protein quantification data, enabling researchers to investigate complex biological processes comprehensively. This method finds extensive applications in biomarker discovery, disease mechanism research, drug target identification, and pharmaceutical development. In medicine, mass spectrometry quantification enhances our understanding of disease pathogene......
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MS protein identification involves measuring the mass-to-charge ratio (m/z) of proteins or protein fragments to determine their molecular mass and infer structural characteristics. Mass spectrometry provides high sensitivity, making it a powerful tool for detecting and identifying proteins in complex biological samples. In the biomedical field, MS protein identification is widely applied in disease biomarker discovery, drug mechanism research, and personalized medicine. By analyzing protein expressi......
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Interactome analysis refers to the study of interactions between proteins and other biomolecules (including proteins, nucleic acids, and lipids) within an organism. Proteins are key molecules responsible for most cellular functions, and their activities depend on forming intricate networks with other biomolecules. Consequently, interactome analysis is essential for elucidating mechanisms underlying intracellular signal transduction, metabolic pathways, and gene expression regulation. This technology......
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• LC-MS Protein Quantification
LC-MS protein quantification integrates liquid chromatography (LC) and mass spectrometry (MS) to identify and quantify proteins in complex biological samples with high accuracy and sensitivity. Liquid chromatography separates proteins or peptides based on their chemical and physical properties, enabling the gradual isolation of individual components from complex samples. This sequential separation allows mass spectrometry to more precisely identify and quantify proteins or peptides. Mass spectrometry,......
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• Antibody Epitope Mapping in Research and Diagnostics
Antibody epitope mapping is a critical technique for identifying and analyzing the interactions between antibodies and their target proteins. An epitope refers to a specific region on an antigen molecule that antibodies can bind with high specificity. Detailed analysis of these epitopes provides insights into antibody specificity and functional properties, playing pivotal roles in basic research, vaccine development, and disease diagnostics. In basic research, antibody epitope mapping facilitates th......
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Biotin Proximity Labeling is a highly effective technique extensively employed in proteomics research to map protein-protein interactions, spatial organization, and dynamic protein behavior. At the core of this approach is the utilization of specialized enzymes, such as biotin ligase BirA or its enhanced variant TurboID, which covalently attach biotin molecules to lysine residues on proteins within their immediate proximity. These enzymes are typically genetically fused with target proteins and direct......
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HCP Characterization is a critical quality control process in biopharmaceutical manufacturing. HCPs refer to residual proteins unintentionally retained from host cell systems, including microbial hosts (e.g., bacteria, yeast) and mammalian cell lines, during the production of therapeutic proteins and biologics. The presence of HCPs can pose immunogenicity and toxicity risks, potentially compromising drug safety and therapeutic efficacy.
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• Hybridoma Antibody Sequencing
Hybridoma antibody sequencing is an advanced analytical technique used to determine the amino acid sequences of antibodies produced by hybridoma cell lines. Hybridoma cells, formed by fusing B lymphocytes with myeloma cells, are capable of continuously producing monoclonal antibodies. In antibody drug development, hybridoma antibody sequencing is widely applied to optimize antibodies for improved stability, efficacy, and safety. By accurately determining the antibody sequence, researchers can gain a......
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• Protein Quantification Mass Spectrometry
Protein quantification mass spectrometry is a powerful analytical technique designed to measure protein levels in complex biological samples with high precision and accuracy. By integrating the sensitivity and specificity of mass spectrometry, it has become an essential tool in modern proteomics research. This technology has extensive applications, including biomarker discovery, disease mechanism elucidation, drug target identification, and the dynamic monitoring of biological processes. In protein ......
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• Edman Sequencing Service in Protein Analysis
Edman sequencing service is a specialized analytical technique used for determining the N-terminal amino acid sequence of proteins with high precision. Named after its inventor, Pehr Edman, this method employs Edman degradation to sequentially cleave amino acids from the N-terminus of a peptide, enabling their identification and quantification. This approach remains one of the most reliable tools for analyzing short peptide sequences, offering valuable insights into protein structure and functional ch......
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