S-Adenosylmethionine Analysis Service
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Please make sure the sample quantity is more than 0.2 g or 0.2 mL.
Cycle: 2-3 weeks
S-Adenosylmethionine (SAM), also known as SAMe, is a crucial cosubstrate involved in methyl transfer, playing a pivotal role in cellular development and differentiation. This molecule is synthesized from ATP and methionine through the action of methionine adenosyltransferase. Its unique molecular structure includes an adenosine unit, a methionine part, and a thiomethyl group, enabling it to donate methyl groups. Thus, SAM is a key participant in methylation processes, acting as a methyl donor for the modification and regulation of DNA, proteins, and lipids. Moreover, SAM serves as a precursor for neurotransmitter synthesis in the central nervous system, essential for the production of neurotransmitters like dopamine, serotonin, and norepinephrine, which are critical for emotional regulation and neurological function.
In bacteria, SAM interacts with the SAM riboswitch to regulate genes involved in the biosynthesis of methionine or cysteine. In eukaryotic cells, SAM acts as a regulator in various processes, including the methylation of DNA, tRNA, and rRNA, as well as in immune responses, amino acid metabolism, and transsulfuration. In plants, SAM is vital for the biosynthesis of ethylene, an important plant hormone and signaling molecule that affects growth and development.
Scientists utilize S-adenosylmethionine analysis to explore cellular methylation dynamics, which propels research in areas like oncology and epigenetics. Therefore, precise and reliable analysis of SAM is crucial for elucidating its physiological and pathological roles. At MtoZ Biolabs, we offer comprehensive S-adenosylmethionine analysis services using cutting-edge mass spectrometry technology.
Figure 1. The Structure of S-Adenosylmethionine
Services at MtoZ Biolabs
At MtoZ Biolabs, our analysis of S-adenosylmethionine typically relies on High-Performance Liquid Chromatography (HPLC) combined with Mass Spectrometry (MS). This combination allows for the precise quantification of SAM concentrations in samples. Moreover, using HPLC-MS provides detailed information about the structure of SAM, aiding in the identification of various methylated metabolites. This enables in-depth analysis of complex biological samples.
Sample Submission Requirements
Deliverables
1.Experimental Procedures
2.Relevant Mass Spectrometry Parameters
3.Detailed Information on S-Adenosylmethionine Analysis
4.Mass Spectrometry Images
5.Raw Data
Please contact us if you have any questions about our S-Adenosylmethionine Analysis Service. At MtoZ Biolabs, we are dedicated to providing our clients with high-quality, reliable and accurate metabolomic analysis services.
How to order?
