Sarcosine Analysis Service

Sarcosine (Methylglycine) is a vital amino acid derivative and an intermediate in creatine metabolism. Sarcosine participates in various biological processes, including methylation reactions and creatine synthesis. Sarcosine is synthesized from glycine by glycine-N-methyltransferase (GNMT) and further metabolized into glycine and methyl donors like S-adenosylmethionine (SAM). This metabolic process is crucial for maintaining methylation balance and energy metabolism in the body. Variations in Sarcosine levels can be linked to conditions such as prostate cancer, schizophrenia, and metabolic disorders. Accurate measurement of Sarcosine concentrations provides insights into its biological roles, aiding in the diagnosis and treatment of related conditions.

Figure 1. Molecular Structure of Sarcosine

MtoZ Biolabs utilizes liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct detailed quantitative and qualitative analyses of Sarcosine and its metabolites. This advanced method integrates LC's rapid separation capabilities with the high detection sensitivity of MS/MS, facilitating the precise measurement of Sarcosine in complex biological matrices.

Analysis Workflow

Service Advantages

• Rapid Analysis Cycle and Cost-Effectiveness
• Stable, Reliable, and Highly Sensitive Results
• Comprehensive One-Stop Service for Extensive Testing Needs
• User-Friendly Operation with Wide Application Scope
• Supported by Extensive Bioanalytical Resources and Advanced Platforms

Sample Submission Requirements

Sample Types

Serum, plasma, urine, tissue homogenates, and other biological samples.

Sample Volume

At least 200 μL of liquid sample or 200 mg of tissue sample.

Sample Preservation

Store and transport samples at -80°C to maintain Sarcosine stability.

Applications

Cancer Research: Detect changes in Sarcosine levels to assist in early diagnosis and prognosis evaluation of prostate cancer.

Psychiatric Research: Analyze changes in Sarcosine levels in patients with schizophrenia to explore its potential role as a biomarker.

Metabolic Research: Study the role of Sarcosine in creatine metabolism and methylation reactions.

Drug Development: Evaluate the impact of new drugs on Sarcosine metabolism to aid in developing therapies targeting specific metabolic pathways.

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Sarcosine and their Metabolites

4. Raw Data

5. Custom Analysis Report

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into Sarcosine's extensive physiological roles through top-tier analytical techniques and expert services.