Sequencing Analysis

• • Different Species Sequencing Service

  MtoZ Biolabs harnesses this diversity, offering different species sequencing services, thus aiding researchers and clinicians in obtaining precise structural and functional insights into antibodies. Our platform functions independently of pre-existing databases, utilizing advanced liquid chromatography-tandem mass spectrometry (LC-MS/MS) along with sophisticated machine learning algorithms.

• • Protein Degradation or Enzyme Digestion Analysis Service

  Protein degradation is crucial for regulating protein function and levels within cells. Specific proteases cleave proteins into smaller fragments, impacting their structure and function, and generating biologically active cleavage products. Understanding degradation pathways and cleavage sites is essential for studying protein function, signal transduction, and metabolic regulation.

• • IgG Antibody Sequencing Service

  Accurate sequencing of IgG antibodies is crucial for diagnosing diseases, developing vaccines, conducting immunological research, and advancing biopharmaceutical applications. MtoZ Biolabs utilizes mass spectrometry (MS) technology combined with bioinformatics to deliver IgG antibody sequencing services that ensure high sensitivity and accuracy, contributing to the advancement of scientific and clinical research.

• • Immobilized Antibody Sequencing Service

  Immobilized antibody sequencing involves attaching antibodies to a solid substrate, such as agarose beads, silica gel matrices, or glass slides, followed by detailed sequencing analysis. This method employs chemical cross-linkers, such as glutaraldehyde or thiol compounds, to securely anchor the antibodies to the substrate, ensuring that their structural integrity and functional activity are maintained during subsequent processing. Once immobilized, the antibodies can be thoroughly analyzed for their amino

• • IgE Antibody Sequencing Service

  Accurate IgE antibody sequencing is critical for the study, diagnosis, and treatment of allergic diseases. MtoZ Biolabs offers cutting-edge IgE antibody sequencing using mass spectrometry (MS) technology, enhanced by extensive bioinformatics expertise. This combination delivers highly sensitive and precise results, advancing both scientific research and clinical practice.

• • Antibody-Drug Conjugate (ADC) Sequencing Service

  Antibody-drug conjugates (ADCs) are composed of three parts: (1) Antibody (Ab): Ab is responsible for targeting specific antigen-expressing cells, usually cancer cells; (2) Cytotoxic drug: Cytotoxic drug is a small molecule drug that is conjugated to the Ab and can be delivered specifically into the cell and released to kill the target cell; (3) Linker: A linker connects the Ab and the drug, ensuring stability during transportation and efficient release of the ADCs at the target site.

• • Sequence and Mutation Analysis Service of Unknown Proteins or Peptides

  In drug development and the production of biological products, it is essential to ensure that proteins are correctly folded and functional. Sequence mutations, whether from errors in DNA replication or incorrect amino acid incorporation during translation, can cause protein dysfunction or inactivation. Accurate identification and analysis of these sequence variations (SVs) are critical for maintaining the quality and efficacy of products. Our services are tailored for analyzing sequence and mutation in unkn