Spatial Metabolomics Service

Mass Spectrometry Imaging (MSI) represents a state-of-the-art molecular imaging technique that directly gathers extensive information on a wide array of endogenous metabolites and exogenous drugs from biological tissues. This method captures details about molecular structures, quantities, and their precise locations in tissues, offering advantages over traditional imaging methods like fluorescence or radioactive labeling by eliminating the need for complex preparatory steps. It boasts high specificity, throughput, and excellent spatial resolution.

 

MSI leverages thousands of metabolic markers for a thorough qualitative, quantitative, and spatial analysis of biological tissue samples. Integrated with bioinformatics, MSI has emerged as a pivotal tool in spatial metabolomics, capable of uncovering in-situ metabolic variations within tissues and their biological implications.

 



Zheng, Y. et al. Front Oncol. 2023.

Figure1. Manufacturing Flow for the Final Spatial Metabolic Images From the Tumor Samples

 

Services at MtoZ Biolabs

MtoZ Biolabs enhances spatial metabolomics with our advanced Aerodynamically Assisted Ionization Desorption Electrospray Ionization Mass Spectrometry Imaging (AFAI-MSI) technology. This method uses a specialized transmission pipeline to extend the reach of charged droplets, aided by airflow. High-speed airflow and voltage settings enhance the desolvation and enrichment of droplets, substantially boosting sensitivity and expanding the operational scope and flexibility for handling samples. This technology is versatile, effective for both small tissue samples and large-volume or distant samples.

 

Sample Submission Requirements

1. Animal tissues: Including organs from mice and rats such as brain, kidney, heart, liver, spleen, spinal cord, pituitary gland, pancreas, and skin.
2. Cancer samples: From cancers like esophageal, thyroid, lung, breast, stomach, glioma, nasopharyngeal, skin, and liver.
3. Plant tissues: Focusing on roots and seeds.

 

Service Advantages

• Our AFAI-MSI technology maximizes ionization efficiency and maintains sample integrity through finely tuned airflow and voltage.
• The system is designed to automatically adjust scanning speed and resolution based on the sample type and specific analytical requirements.

 

MtoZ Biolabs is committed to partnering with you to tailor solutions that meet your project's unique demands. For further inquiries or specific needs related to spatial metabolomics, please contact us. Our team of experts is ready to provide specialized advice and support.