Targeted Metabolomics

Targeted metabolomics is a specialized technique designed to accurately identify and quantify specific metabolites within defined metabolic pathways or biological processes. Unlike untargeted metabolomics, which offers a broad overview of all detectable metabolites, targeted metabolomics focuses on known compounds, providing enhanced sensitivity, specificity, and precise quantification. It is particularly useful for validating metabolic biomarkers discovered through untargeted approaches or for conducting targeted analyses of specific metabolite classes.

 

The process begins by developing detection methods using standard compounds, followed by multiple reaction monitoring (MRM) technology to perform precise qualitative and quantitative assessments. This method allows researchers to track changes in specific metabolic pathways with high accuracy, offering deeper insights into disease-associated metabolic profiles, regulatory mechanisms, and drug metabolism.

 

MtoZ Biolabs utilizes ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for targeted metabolomics analysis. This advanced technology combines efficient UPLC separation with high-sensitivity MS/MS detection, ensuring accurate identification and quantification of various target metabolites in complex biological samples.

 

Analysis Workflow

 



 

Service Advantages

 



 

Sample Submission Requirements

 



For detailed sample submission instructions, please consult our technical team.

 

Applications

1. Disease Research: Analyze disease-related metabolites to uncover the metabolic characteristics of diseases, aiding in disease diagnosis and treatment.

 

2. Drug Metabolism Research: Evaluate drug metabolism pathways and their metabolites in the body, supporting new drug development and efficacy evaluation.

 

3. Nutritional Research: Study the metabolic processes of specific nutrients in the body, assessing their bioavailability and health benefits.

 

4. Biomarker Discovery: Discover new biomarkers through targeted metabolomics for early disease diagnosis and prognosis evaluation.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Metabolites

4. Raw Data

5. Custom Analysis Report