Taurodehydrocholic Acid Analysis Service

Taurodehydrocholic acid (TDHCA) is a significant bile acid derivative involved in lipid metabolism and cholesterol homeostasis within the body. As a taurine-conjugated metabolite of dehydrocholic acid, TDHCA holds a pivotal role within the bile acid metabolic network. Comparative studies on bile acids, such as taurodeoxycholic acid, have demonstrated functions including mitochondrial membrane stabilization, reduction of free radical formation, and inhibition of apoptosis through the blockage of calcium-mediated apoptotic pathways and Caspase-12 activation. These properties underscore its neuroprotective potential, particularly in the context of 3-nitropropionic acid-induced or genetic models of Huntington's disease (HD) in mice.

 

In light of these findings, the analysis of TDHCA is academically valuable for advancing our understanding of bile acid metabolism, assessing liver function, and investigating diseases associated with bile acid dysregulation. Detailed analysis of TDHCA levels and functions may reveal its contributions to various physiological and pathological processes, including cholestasis, liver disorders, and metabolic abnormalities.

 

Figure 1. Molecular Structure of Taurodehydrocholic Acid

 

MtoZ Biolabs offers Taurodehydrocholic Acid Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in TDHCA detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity

Detects very low concentrations of TDHCA accurately.

 

2. High Specificity

Differentiates TDHCA from other compounds using mass spectrometry.

 

3. Rapid Analysis

Efficient sample preparation and fast detection processes for high-throughput analysis.

 

4. High Accuracy

Strict quality control ensures accuracy and reproducibility.

 

5. Versatility

Capable of analyzing TDHCA and its related metabolites.

 

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Taurodehydrocholic Acid

4. Raw Data

5. Custom Analysis Report

 

Our Taurodehydrocholic Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.