Taurohyocholic Acid Analysis Service

Taurohyocholic acid (THCA) is the taurine-conjugated form of the primary porcine bile acid, hyocholic acid. THCA plays a vital role in the emulsification and absorption of dietary fats. The conjugation of taurine to the bile acid enhances its solubility in the intestinal tract, thereby facilitating fat digestion and absorption, which is crucial for normal lipid metabolism.

 

Beyond its role in lipid metabolism, THCA also inhibits cholesterol crystal precipitation by stabilizing cholesterol in the liquid-crystalline phase. This stabilization effectively prevents cholesterol-induced cholestasis and cellular necrosis, which are essential for maintaining liver health. For instance, studies have demonstrated that THCA can prevent taurolithocholic acid-induced cholestasis and cellular necrosis in isolated rat livers. Additionally, elevated levels of THCA have been detected in the urine of patients with hepatitis B-induced cirrhosis, highlighting its potential as a biomarker for liver diseases.

 

Therefore, accurate detection and analysis of THCA are critical for understanding its role in lipid metabolism, liver diseases, and related pathological conditions.

 

Figure 1. Molecular Structure of Taurohyocholic Acid

 

MtoZ Biolabs offers Taurohyocholic Acid Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in THCA detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity

Detects very low concentrations of THCA accurately.

 

2. High Specificity

Differentiates THCA from other compounds using mass spectrometry.

 

3. Rapid Analysis

Efficient sample preparation and fast detection processes for high-throughput analysis.

 

4. High Accuracy

Strict quality control ensures accuracy and reproducibility.

 

5. Versatility

Capable of analyzing THCA and its related metabolites.

 

Sample Submission Requirements

Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Taurohyocholic Acid

4. Raw Data

5. Custom Analysis Report

 

Our Taurohyocholic Acid Analysis Service provides high-quality data support, advancing your scientific research and applications. For any inquiries or requirements, please contact us.