Thapsigargin Analysis Service

Thapsigargin is a potent natural compound extracted from the Mediterranean plant Thapsia garganica, renowned for its bioactivity. It is a highly effective inhibitor of the endoplasmic reticulum calcium ATPase, inducing calcium influx and triggering apoptosis. Thapsigargin holds significant promise in cancer research due to its ability to induce programmed cell death. It is extensively used in basic research and plays a crucial role in drug development and therapeutic strategy studies. Therefore, accurately measuring thapsigargin levels and metabolism is essential for understanding its mechanisms and applications.

 

Figure 1. Molecular Structure of Thapsigargin

 

MtoZ Biolabs offers Thapsigargin Analysis Service using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). This advanced method combines the separation capabilities of UPLC with the detection power of MS, ensuring high sensitivity and specificity in thapsigargin detection.

 

Analysis Workflow

 



 

Service Advantages

1. High Sensitivity and Precision

UPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of thapsigargin.

 

2. Rapid and Efficient

Optimized sample preparation and fast analysis ensure quick and efficient processing.

 

3. Wide Applicability

Suitable for various biological samples, including blood, urine, and tissues.

 

4. Accurate and Reliable Data

Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

 

Sample Submission Requirements

 

 

For detailed sample submission instructions, please consult our technical team.

 

Applications

• Measure thapsigargin levels to study its mechanisms in inducing cancer cell apoptosis, exploring new therapeutic strategies.
• Evaluate the potential of thapsigargin in new drug development, supporting the research of anticancer drugs.
• Analyze the toxicity of thapsigargin on cells and organisms, assessing its safety.
• Investigate the role of thapsigargin in cell signaling and calcium homeostasis, understanding its fundamental biological functions.
• Assist in diagnosing calcium regulation-related diseases and evaluating treatment efficacy.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Thapsigargin

4. Raw Data

5. Custom Analysis Report