The Immune Peptidome
The immune peptidome, also referred to as the "Immunopeptidome," encompasses the repertoire of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface. These peptides are derived from the degradation of intracellular proteins and are displayed to facilitate T cell recognition of specific antigens via T cell receptors (TCRs), enabling targeted immune responses. Investigations into the immune peptidome enhance our understanding of how the immune system detects and responds to pathogenic threats, tumorigenic changes, and alterations in self-tissues. Such research also holds critical implications for the development of vaccines, cancer immunotherapies, and treatments for autoimmune disorders.
The exploration of the immune peptidome integrates methodologies from diverse disciplines, including proteomics, immunology, and bioinformatics. Advanced techniques such as mass spectrometry for peptide identification, T cell isolation and functional analysis, and computational simulations play pivotal roles in characterizing the peptides presented by MHC molecules. These efforts contribute to uncovering the underlying mechanisms of immune recognition and provide essential theoretical and technological foundations for advancing immunotherapeutic innovations.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
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