Transcriptomics and Proteomics Service
Transcriptomics and proteomics are two complementary fields that are integral to understanding the molecular mechanisms governing cellular function. Transcriptomics refers to the study of the RNA molecules produced by the genome under specific conditions, providing insight into gene expression levels, alternative splicing, and post-transcriptional regulation. Proteomics, on the other hand, focuses on the large-scale study of proteins, including their functions, interactions, modifications, and abundance within a cell or tissue. Together, transcriptomics and proteomics offer a comprehensive view of how genes are translated into the proteins that carry out cellular processes, offering valuable insights into health, disease, and development.
The role of transcriptomics and proteomics in modern research is indispensable. In disease studies, transcriptomics helps researchers identify alterations in gene expression that may contribute to conditions such as cancer, neurodegenerative diseases, and metabolic disorders. Meanwhile, proteomics enables the study of protein alterations, interactions, and functions that drive these diseases at a molecular level. Together, transcriptomics and proteomics play a pivotal role in drug discovery, biomarker identification, and therapeutic development.
Figure 1. Integrating Transcriptomics and Proteomics to Decipher Disease Biology
Service at MtoZ Biolabs
MtoZ Biolabs offers a comprehensive Transcriptomics and Proteomics Service designed to assist researchers in gaining a deeper understanding of biological systems. Our Transcriptomics and Proteomics Service enables clients to perform high-resolution analyses of both RNA and protein profiles in their samples, offering insights into gene expression, protein functions, and molecular interactions. Whether you are studying disease mechanisms, developing new therapies, or exploring cellular pathways, our Transcriptomics and Proteomics Service provides the tools you need to accelerate your research and uncover new biological insights.
Figure 2. Workflow for Transcriptomics and Proteomics Profiling of Aerial Organ Development in Arabidopsis
Service Advantages
1. Panoramic Expression Profiling
Integrates transcriptomics and proteomics to comprehensively analyze mRNA and protein expression levels, revealing a complete molecular landscape in specific biological states.
2. In-Depth Regulatory Pathway Analysis
By uncovering differential expression patterns, Transcriptomics and Proteomics Service identifies critical mRNAs and proteins regulated post-transcriptionally, helping pinpoint essential pathways and molecular mechanisms.
3. Improved Protein Identification coverage
For species with incomplete or poorly annotated protein databases, transcriptome data can be used to build protein search libraries, significantly improving protein identification coverage.
4. Advanced Analysis Platform
MtoZ Biolabs established an advanced Transcriptomics and Proteomics Service platform, guaranteeing reliable, fast, and highly accurate analysis service.
5. One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
6. High-Data-Quality
Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrates all Transcriptomics and Proteomics Service data, providing clients with a comprehensive data report.
Applications
With Transcriptomics and Proteomics Service, we provide integrated solutions to address diverse research needs across multiple fields:
1. Medical Research: Facilitates tumor mechanism analysis, disease classification, and biomarker identification for accurate diagnostics.
2. Drug Development: Provides in-depth insights into drug targets, mechanisms of action, and efficacy evaluations.
3. Crop and Plant Research: Advances plant growth studies, breeding strategies, and stress tolerance mechanisms for agroforestry.
4. Food Quality and Safety: Assists in component identification, functional food development, and safety testing to ensure food quality.
5. Microbial Mechanism Exploration: Deciphers pathogen-host interactions, drug resistance pathways, and microbial pathogenesis.
6. Comprehensive Molecular Profiling: Offers integrated analysis of gene expression and protein dynamics for holistic biological insights.
Case Study
Integrated Transcriptomics and Proteomics Landscape of Macrophages in Mouse Tissues
This case study highlights the integration of transcriptomics and proteomics to analyze distinct macrophage populations in mice. Researchers profiled 10 primary macrophage populations from seven tissues, bone marrow-derived macrophages, and a cell line using mass spectrometry and RNA sequencing. The results revealed unique proteomic landscapes and transcriptomic patterns, showing functional specialization between tissue-resident and recruited macrophages. By constructing hierarchical regulatory networks, cell-type-specific transcription factors were identified as key regulators of macrophage identity. Notably, the cytokine Il18 was validated as a critical factor distinguishing molecular signatures and functional characteristics in lung and liver macrophages. This study demonstrates the power of combining transcriptomics and proteomics analyses to achieve comprehensive molecular profiling, uncover key regulatory factors, and understand cellular specialization in diverse environments. Such integrative approaches provide critical insights into immunology, disease mechanisms, and tissue homeostasis, showcasing the utility of Transcriptomics and Proteomics Service for advancing biological and medical research.
Qie, J. et al. Nat Commun. 2022.
Figure 3. The Transcriptomics and Proteomics Atlases of Ten Primary Macrophage Populations from Seven Tissues, BMDMs, and RAW264.7 Cells
Deliverables
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Relevant Liquid Chromatography and Mass Spectrometry Parameters
4. The Detailed Information of Transcriptomics and Proteomics
5. Mass Spectrometry Image
6. Raw Data
How to order?
