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    Tricarboxylic Acid Cycle Metabolism Service

      The tricarboxylic acid (TCA) cycle, also known as Krebs cycle or citric acid cycle, is a series of biochemical reactions that take place in the mitochondria and are part of cellular respiration. These reactions convert glucose, fats and proteins into carbon dioxide, water and energy, which are essential for the cell's metabolic needs. Understanding the dynamics of TCA cycle is crucial in various research fields including biochemistry, cell biology, and medical sciences. MtoZ Biolabs is proud to offer a comprehensive Tricarboxylic Acid Cycle Metabolism Service to support your research.

       

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      Figure 1. The Overview of Tricarboxylic Acid Cycle

       

      Services at MtoZ Biolabs

      At MtoZ Biolabs, we utilize state-of-the-art mass spectrometry technologies, coupled with advanced metabolomics data analysis software, to accurately measure the metabolites in the TCA cycle. Our platform enables precise quantification of TCA intermediates such as citrate, isocitrate, α-ketoglutarate, succinate, fumarate, and malate, among others. This allows researchers to understand the dynamics of TCA cycle in detail, and how it is regulated under different physiological and pathological conditions.

       

      Analysis Workflow

       

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      Service Advantages

      • State-of-the-art mass spectrometry technology with high sensitivity and accuracy
      • Comprehensive data analysis supported by a team of experienced analysts
      • Strict quality control to ensure reliable results
      • Personalized service to meet various research needs

       

      Applications

      Our Tricarboxylic Acid Cycle Metabolism Service can be applied in a variety of research scenarios, including but not limited to:

      • Studying the effects of drugs or other treatments on TCA cycle.
      • Investigating the role of TCA cycle in various diseases.
      • Understanding the metabolic changes during different physiological conditions.

       

      Sample Submission Requirements

      Please ensure that your samples meet the following requirements:

      • Fresh or frozen tissues/cells should be submitted on dry ice.
      • The minimum amount of sample required is >200 mg for tissues, >1 x 10⁷ for cells.
      • Please provide detailed information about your samples, including species, tissue/cell type, etc.

       

      Deliverables

      1. Experimental Procedures

      2. Relevant Mass Spectrometry Parameters

      3. Detailed Information on Tricarboxylic Acid Cycle Metabolism Analysis

      4. Mass Spectrometry Images

      5. Raw Data

       

      At MtoZ Biolabs, we are committed to providing you with quality services to support your research. Contact us today to learn how our Tricarboxylic Acid Cycle Metabolism Service can advance your research.

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