UV Spectroscopy Analysis of Peptide Drugs

Polypeptide drugs are bioactive molecules formed by the connection of multiple amino acids through peptide bonds. Generally speaking, they are connected by 10~100 amino acids with a relative molecular mass lower than 10000. Most polypeptide drugs come from endogenous peptides or natural peptides, so they have no side effects or very small side effects on the human body. Compared with protein drugs, polypeptide drugs have the advantages of good stability, high purity, low production cost, low immunogenicity, etc. With the rapid development and maturity of peptide synthesis technology, polypeptide drugs have become the focus of biopharmaceutical research in recent years. At present, polypeptide drugs have been widely used in the diagnosis and treatment of tumors, autoimmune diseases and certain cardiovascular diseases, diabetes, etc., with broad application prospects.

 

Spectral technology is widely used to study the secondary structure of polypeptide drugs, such as ultraviolet spectroscopy. The biggest advantage of this technology is that it takes less time and can quickly obtain relevant information. Ultraviolet spectroscopy can obtain information about molecular structure and functional groups, which is extremely important for the research and development of polypeptide drugs. In addition, ultraviolet spectroscopy can also be used to study the structure, stability and folding state of polypeptide drugs. By measuring their absorption spectra in the ultraviolet region, information about their secondary and tertiary structures can be obtained.

 

MtoZ Biolabs Biotechnology provides customers with drug quality research services that comply with global pharmaceutical regulations. We provide one-stop UV spectroscopy analysis services for polypeptide drugs, suitable for qualitative and quantitative analysis of polypeptide drugs with conjugate systems or containing specific functional groups.