X-Ray Powder Diffraction Determination of Antibody Drug

Antibody drugs are a type of drugs that treat diseases through artificially synthesized antibodies. They achieve their therapeutic purpose by specifically binding with target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, antibody-drug conjugates, and others. Antibody drugs have demonstrated significant efficacy in treating various diseases, such as cancer, autoimmune diseases, inflammatory diseases, immunoregulation, and ophthalmic diseases.

 

As of now, the main methods for determining the spatial structure of antibody drugs include X-ray diffraction (XRD), nuclear magnetic resonance technology (NMR), and electron microscopy. Among them, X-ray diffraction is one of the most accurate methods for determining protein structure, with over 80% of known protein structures obtained using this method. X-ray diffraction includes X-ray single crystal diffraction and X-ray powder diffraction, with the latter having a wider range of detection objects, which can be crystalline or non-crystalline solid samples.

 

MtoZ Biolabs provides drug quality research services that comply with global pharmaceutical regulations. Based on our existing technology platform, we offer one-stop X-ray diffraction measurement services for antibody drugs. By obtaining cell parameters, such as interatomic distances, ring plane distances, and dihedral angles, we can determine the crystal form and structure of protein drugs.