Do "Self-MHC Molecules," Recognized by T Cells, Belong to the T Cells Themselves or to the Host Organism?
The term "self-MHC molecules" refers specifically to the MHC molecules of the host organism. T cells recognize antigenic peptides presented by MHC molecules through the T-cell receptors (TCRs) located on their surface, a critical immunological process known as antigen presentation. Certain specialized cells within the immune system, including dendritic cells, macrophages, and B cells, are responsible for antigen capture, processing, and presentation; these cells are collectively termed professional antigen-presenting cells (APCs).
CD8+ T cells recognize antigenic peptides presented by class I MHC molecules, which are expressed on the surface of all nucleated cells within the organism. In contrast, CD4+ T cells recognize antigenic peptides presented by class II MHC molecules, primarily found on APCs. Importantly, during antigen recognition, T cells interact with the host organism's own MHC molecules, not with those expressed on the T cells themselves.
This recognition mechanism enables the immune system to distinguish effectively between self and non-self antigens, facilitating appropriate responses against pathogens while preventing harmful autoimmune reactions against host tissues.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
Related Services
How to order?
