Protein Molecular Weight Determination Analysis Service

Molecular weight is a critical measure of biomolecule size, including proteins, peptides, and nucleic acids, in biopharmaceuticals. It significantly influences drug efficacy, stability, biological activity, and safety. Evaluating the molecular weight provides insights into a biopharmaceutical's structural complexity, purity, and post-translational modifications, essential for assessing drug quality, efficacy, and safety. Variations in molecular weight can affect drug performance and may be linked to adverse reactions. Predominant techniques for molecular weight determination are MALDI-TOF and ESI-MS. MALDI-TOF offers a rapid assessment suitable for biomolecules, while ESI-MS provides high sensitivity for complex samples.

 

Services at MtoZ Biolabs

MtoZ Biolabs, as an innovative company in the field of biopharmaceutical analysis, offers a sophisticated molecular weight determination service utilizing state-of-the-art mass spectrometry technologies. Our molecular weight analysis services are designed to support the precise needs of the biopharmaceutical industry. From confirming protein structures to conducting detailed peptide mapping, MtoZ Biolabs tailors its offerings to suit the unique requirements of each client. Our facility is equipped with the latest in mass spectrometry technology, including both ESI-MS and MALDI-TOF systems, enabling us to accurately measure the molecular weight of a diverse range of biopharmaceuticals such as therapeutic proteins, antibodies, peptides, and vaccines. Free project evaluation, welcome to learn more details! Our technical specialists are available to provide a free business assessment.

 



Figure 1. Biopharmaceutical analysis at MtoZ Biolabs

 

Analysis Workflow

1. Sample Preparation: Treating the biological sample to ensure compatibility with mass spectrometric analysis.

2. Ionization: Employing electrospray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI) to ionize the sample molecules.

3. Mass Analysis: Determining the ions' mass-to-charge ratio (m/z) using time-of-flight (TOF-MS) or quadrupole mass spectrometers (Q-MS).

4. Data Analysis: Employing specialized software to process and interpret the data, yielding precise molecular weight measurements.

 

Applications

1. Protein Identification: Verifying protein molecular weights and structures.

2. Drug Development: Checking drug molecule purity and integrity.

3. Biomarker Discovery: Identifying potential diagnostic markers through molecular weight analysis.

4. Basic Research: Exploring biomolecule functions and mechanisms via molecular weight assessments.

 

Service Advantages

1. Advanced Technology: We use cutting-edge MALDI-TOF and ESI-MS technologies to deliver precise and efficient molecular weight measurements.

2. Experienced Team: Our experts provide professional molecular weight analysis services, drawing on extensive experience in biopharmaceutical applications.

3. Comprehensive Service: We manage all aspects of molecular weight analysis, from sample preparation to final data interpretation, catering to various client needs.

4. Rapid Response: We guarantee swift analysis and timely reporting following sample receipt.

 

Deliverables

1. Experimental Procedures

2. Relevant Mass Spectrometry Parameters

3. Detailed Information on Molecular Weight Determination

4. Mass Spectrometry Images

5. Raw Data