Resources

• • Exploring HCP Diversity: Unraveling Virus-Host Interaction Mechanisms

  Host cell protein (HCP) residuals are common impurities in the manufacturing process of biopharmaceuticals. They are proteins from the host cells used in the bioreactor system, co-expressed and present in the final drug formulation. The presence of HCP residuals can potentially impact the quality and safety of the drug, making it important to explore and analyze the diversity of HCP residuals.

• • Host Protein Residual Validation Guide: Effective Sample Analysis

  Host protein residual verification is an important step in the development of biological drugs, used to confirm the presence of host cell-derived host protein residuals in the drug formulation. Host proteins refer to the proteins produced by host cells (usually mammalian cells) during the production of biological drugs. These host proteins may remain in the final drug formulation, potentially affecting the quality and safety of the drug.

• • Detection of Membrane Proteins Based on Differential Scanning Fluorimetry

  Membrane proteins play crucial roles in cellular processes, including signal transduction, transport, and cell communication. Their detection and analysis are vital for understanding their functions and implications in health and disease. Differential Scanning Fluorimetry (DSF) has emerged as a powerful technique for studying membrane proteins, offering insights into their stability and interactions.

• • Dynamic Proteomics Analysis Using Shotgun Proteomics Techniques

  Dynamic proteomics focuses on understanding the temporal changes in protein expression, modification, and interaction within cells, in response to various stimuli or under different physiological conditions. This field aims to map out the dynamic processes that govern cellular functions and adaptations. Shotgun proteomics, with its ability to identify and quantify thousands of proteins simultaneously, is particularly well-suited for dynamic proteomics studies.

• • Identification and Quantification of Proteins in Complex Samples Using Shotgun Proteomics

  Proteomics is a rapidly advancing field dedicated to the large-scale study of proteins, which are vital to understanding cellular processes and disease mechanisms. Shotgun proteomics, a high-throughput mass spectrometry-based technique, has become a cornerstone for identifying and quantifying proteins in complex biological samples.

• • Quantitative Analysis of Proteins and Modifications by Shotgun Proteomics

  Quantitative proteomics is an essential field in molecular biology, enabling researchers to measure protein abundance and understand post-translational modifications (PTMs) that regulate protein function. Shotgun proteomics, a high-throughput mass spectrometry-based approach, has revolutionized the ability to perform these analyses comprehensively.

• • Comprehensive Analysis of Protein Identification by Shotgun Proteomics

  Protein identification is a cornerstone of proteomics, essential for understanding cellular processes, disease mechanisms, and biological functions. Shotgun proteomics has emerged as a powerful approach to comprehensively analyze and identify proteins within complex biological samples.

• • Comparative Analysis of Proteins in Complex Mixtures Using Shotgun Proteomics

  Shotgun proteomics has revolutionized the field of proteomics because it enables the comprehensive analysis and comparison of proteins in complex biological mixtures. This technique utilizes mass spectrometry (MS) to identify and quantify thousands of proteins simultaneously, offering unparalleled insights into the proteome's composition and dynamics.

• • Procedure for Gel and IP Sample Protein Identification Based on Mass Spectrometry

  Protein identification is fundamental in biochemistry and molecular biology, enabling researchers to elucidate protein structure, function, and interactions. Mass spectrometry (MS) is a powerful analytical technique often used in conjunction with gel electrophoresis (gel) and immunoprecipitation (IP) for detailed protein analysis.

• • Macromolecular Mass Analysis Based on MALDI-TOF and Nano LC-MS

  Understanding the precise mass and structural composition of macromolecules is pivotal in biochemistry, molecular biology, and materials science. Advanced mass spectrometry techniques, particularly Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) and Nano Liquid Chromatography-Mass Spectrometry (Nano LC-MS), have revolutionized the field by providing detailed insights into the molecular weight and structural features of complex biomolecules.