Resources
Proteomics Databases
Metabolomics Databases
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Isoform analysis refers to the identification, characterization, and quantification of compounds-known as isoforms-that share the same molecular formula but differ in their structures or spatial arrangements. In chemical and biological research, isoforms refer to molecules with identical chemical formulas but distinct molecular structures or stereochemical configurations. These structural differences often lead to significant variations in physicochemical properties, biological activities, metabolism,......
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The complete amino acid profile provides a detailed qualitative and quantitative analysis of both essential and non-essential amino acids, offering critical insights into protein composition and function. This analysis plays an essential role in fields such as protein research, biomedicine, food science, and agriculture. Amino acids, as the fundamental building blocks of proteins, are vital for numerous biological processes. Analyzing the complete amino acid profile allows researchers to understand pr......
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The protein pulldown assay is a widely employed in vitro technique for analyzing protein-protein interactions. By using a tagged bait protein to capture interacting partners, this method provides critical insights into protein relationships, binding affinity, and interaction specificity. Compared to yeast two-hybrid and co-immunoprecipitation assays, the protein pulldown assay offers direct and specific detection of interactions in a controlled environment. Its simplicity, high sensitivity, and abilit......
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Enzyme analysis involves investigating enzyme activity, kinetics, catalytic mechanisms, and regulatory effects (inhibition or activation) using a variety of experimental and technical approaches. Enzymes, which are protein or RNA molecules, act as biological catalysts, facilitating chemical reactions both intracellularly and extracellularly. They are often referred to as the "catalysts of life." The primary objective of enzyme analysis is to comprehensively understand enzymatic catalytic properties, r......
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• Transcriptomics and Proteomics
Transcriptomics and proteomics represent two complementary approaches for studying gene expression at different molecular levels. Transcriptomics focuses on RNA analysis to explore gene expression patterns, regulatory relationships, and the influence of environmental factors. In contrast, proteomics investigates the final gene expression products-proteins-examining their composition, structure, function, and interactions. As proteins directly execute cellular functions, proteomics offers critical ......
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• Overview of Full Amino Acid Profile
The full amino acid profile represents the qualitative and quantitative analysis of amino acids obtained by breaking down proteins into their individual amino acid components. This analysis reveals the amino acid composition of proteins and offers insights into their structure, function, and biological activity. The full amino acid profile is widely applied in proteomics, structural biology, and clinical diagnostics. By analyzing amino acid sequences and their proportions, researchers can est......
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Single-cell proteomics (SCP) represents a forefront area of biological research, dedicated to profiling protein expression patterns and their dynamics at the single-cell level. Traditional proteomics methods predominantly focus on population or tissue-scale analyses, limiting their capacity to resolve cellular heterogeneity. However, such heterogeneity is critical for understanding tissue functionality, biological mechanisms, and disease progression, underscoring the need for precise single-cell detec......
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• Introduction and Applications of CUT&Tag Technology
CUT&Tag (Cleavage Under Targets and Tagmentation) is an advanced technique designed for the study of DNA-protein interactions, primarily employed to identify the binding sites of transcription factors or histone modifications across the entire genome. The core principle of CUT&Tag involves the use of antibodies to specifically recognize target proteins or chromatin modifications, followed by the action of the Tn5 transposase, which generates sequencing-compatible tags at these binding sites. First......
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• The Hot Topic in Chromatin Biology: Insights into Histone Modification and CUT&Tag
Histone modifications are essential regulators of chromatin structure and gene expression, playing crucial roles in maintaining cellular function, genomic stability, and facilitating processes such as cell differentiation. Within the cell nucleus, DNA directs the synthesis of RNA and proteins, ensuring proper organismal function. DNA exists as a double helix and wraps around histones to form nucleosomes, which serve as the fundamental units of chromatin. Nucleosomes are organized into a bead-on-a-string...
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• Protein Characterization Services
Protein characterization services encompass analytical techniques designed to determine the physicochemical properties, structural features, and biological functions of proteins. As essential functional molecules in living organisms, proteins exhibit diverse structures and functions that underpin their critical roles in biological processes. Accurate protein characterization is vital for understanding protein behavior in cellular systems, tracking protein alterations in disease states, and identifying......
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