Resources

• • New Breakthrough in Epitope Analysis: Decoding with Amino Acid Diversity

  Analysis of antigenic epitopes is an important research direction in the field of biopharmaceutics, focusing on the interaction between antigens and antibodies. Antigenic epitopes are specific regions on antigen molecules that can bind to antibodies, and they are of great significance in vaccine design, drug development, and immunotherapy.

• • How to Measure Protein Purity: Minimum Protein Required from Sample to Result

  Protein is one of the fundamental molecules in living organisms, and it plays important biological functions within the cells. Therefore, studying the purity and structure of proteins is crucial for understanding the basic principles of life systems. In the field of biopharmaceuticals, determining the purity of proteins is extremely critical as it directly affects the quality and efficacy of drugs.

• • How to Identify Peptide Structure?

  Peptides are bio-macromolecules composed of amino acid residues connected by peptide bonds. They possess a wide range of biological activities and pharmacological effects. Understanding the structure of peptides is crucial for studying their functions and developing related drugs. However, peptide structure determination is a complex and critical task.

• • Analysis of Monosaccharide Diversity and Biopharmaceutical Testing

  Biological drugs are a class of drugs prepared using biotechnology, characterized by high specificity and complexity. In the development and production process of biological drugs, strict quality inspection is crucial. One important parameter for inspection is the diversity of monosaccharide composition.

• • Mechanism of N-Glycan Detection via HILIC-UHPLC-MS

  N-glycans are polysaccharides attached to proteins that play a crucial role in various biological processes, including cell recognition, signaling, and immune responses. The analysis and detection of N-glycans are significant for both fundamental research and clinical applications.

• • Application of Hydrogen-Deuterium Exchange Mass Spectrometry in Proteomics

  Hydrogen-deuterium exchange mass spectrometry (HDX-MS), as a powerful tool, has played an important role in proteomics research. This article will introduce the principles of hydrogen-deuterium exchange mass spectrometry and its applications in proteomics. Principles of Hydrogen-Deuterium Exchange Mass Spectrometry Hydrogen-deuterium exchange mass spectrometry is a structural biology method based on mass spectrometry technology, used to study protein structure and dynamic changes.

• • Application of MALDI-TOF-MS in N-Glycan Profiling

  N-glycans are polysaccharides attached to proteins through glycosylation modifications, prevalent in biological systems. They play critical roles in biological processes, including cell signaling, immune responses, and cell recognition. As research in glycobiology progresses, the demand for efficient N-glycan analysis has surged.

• • Workflow of N-Glycan Profiling for Structural Analysis

  N-glycans, polysaccharides attached to proteins via glycosylation, have complex structures and essential functions. Understanding the structure of N-glycans is crucial for elucidating their biological roles.

• • Advantages and Disadvantages of N-Glycan Profiling Using HILIC-UHPLC-MS

  N-glycans are polysaccharides attached to proteins through glycosylation modifications, widely present in living organisms. They play crucial roles in biological processes such as cell signaling, immune responses, and cell recognition. As research in glycobiology deepens, the demand for efficient analysis of N-glycans has increased.

• • Principle of N-Glycan Profiling Based on MALDI-TOF-MS

  Glycosylation refers to the process of carbohydrates binding to proteins, lipids, or other biomolecules, playing a crucial role in cellular signaling, immune responses, and protein stability. N-glycosylation, a major form of glycosylation, involves oligosaccharide chains attached to amino acid residues. In recent years, N-glycan analysis based on Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) has become a focus of attention for researchers.