Resources
Proteomics Databases
Metabolomics Databases
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• Single Cell Protein Analysis
Single cell protein analysis is a transformative technology that enables the detection and quantification of intracellular protein composition and dynamic changes at single-cell resolution. Compared to traditional bulk proteomics methods, this approach offers significantly enhanced sensitivity and resolution, allowing researchers to study cellular heterogeneity and functional characteristics in unprecedented detail. In multicellular organisms, individual cells exhibit substantial diversity influenced ......
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• Protein Characterization Assays
Protein characterization assays are critical analytical techniques used to investigate the structure, function, and interactions of proteins. Proteins, as central molecules in cellular processes, perform diverse biological functions, including catalyzing biochemical reactions, transmitting cellular signals, and maintaining structural integrity. Through detailed analysis of the physical and chemical properties of proteins, these assays can provide insights into three-dimensional structures, post-transl......
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mAb characterization involves the comprehensive analysis and evaluation of the structure, function, and purity of monoclonal antibodies. In biotechnology and pharmaceutical development, mAbs are highly valued for their exceptional specificity and broad applications in disease diagnosis and therapy. Characterization aims to ensure the stability, efficacy, and safety of these biomolecules across development, production, and clinical use. Key aspects of mAb characterization include amino acid sequence ve......
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Protein pathway analysis is a fundamental technique in bioinformatics and systems biology, aimed at elucidating complex biological processes and functional mechanisms by studying proteins and their interaction networks. At its core, the analysis focuses on identifying and interpreting protein-protein interactions, offering insights into cellular functions, signaling pathways, metabolic networks, and disease mechanisms. By constructing protein interaction maps, researchers can identify functional modul......
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• HCP Analysis by Mass Spectrometry
In the biopharmaceutical industry, host cell proteins (HCPs) refer to residual contaminant proteins derived from host cells during the production process. These proteins can co-purify with therapeutic products, posing potential risks to the safety and efficacy of the final product. Therefore, rigorous detection and control of HCPs are essential. HCP analysis by mass spectrometry is a highly sensitive and reliable approach for identifying and quantifying these contaminants, ensuring product purity and ......
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• Advances in HPLC Protein Analysis
HPLC protein analysis is a key technique in proteomics research, widely employed for protein separation and characterization. The method relies on using a liquid mobile phase under high pressure to flow through a chromatographic column containing a stationary phase, enabling the separation of components in a protein mixture. Given the complexity and diversity of proteins, HPLC protein analysis plays an essential role in evaluating protein purity, identifying protein modifications, quantifying protein ......
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Proteomics sequencing is an advanced analytical technology designed to comprehensively study the entire protein complement of an organism, playing a central role in understanding biological processes. Proteins function as molecular machines, executing essential tasks such as maintaining cellular structures, catalyzing biochemical reactions, and regulating physiological processes. Following the completion of the Human Genome Project, scientists recognized that decoding the genome-wide expression of gen......
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ABPP proteomics, short for activity-based protein profiling, is an advanced chemical probe-based technology designed to investigate protein functional states and activities. It enables monitoring and regulation of protein activity by employing specialized chemical probes that form stable covalent bonds with active sites in proteins. This approach is widely applied in modern biomedical research, particularly in drug discovery, disease mechanism elucidation, and biomarker identification. At the heart of......
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LC-MS proteomics is an analytical technique that integrates liquid chromatography (LC) and mass spectrometry (MS) to comprehensively study proteins in complex biological samples. At its core, this technology harnesses the separation efficiency of LC and the identification precision of MS, enabling scientists to perform protein identification, quantification, and post-translational modification analyses. LC-MS proteomics is indispensable in proteomic research, offering insights into intracellular prote......
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• Identification of Drug Targets
The identification of drug targets involves determining biomacromolecules, such as proteins, nucleic acids, and carbohydrates, that interact with drug molecules using various experimental and computational techniques. These targets are typically molecules associated with disease processes, playing critical roles in disease onset, progression, and development. As a cornerstone of drug discovery, target identification enhances our understanding of disease mechanisms, enables the identification of key mo......
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