Resources
Proteomics Databases
Metabolomics Databases
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• Advancements in Peptide Synthesis Methods Applications and Innovations
Peptide synthesis refers to the chemical or biological assembly of amino acids in a defined sequence to form peptide chains. Peptides, typically composed of 50 or fewer amino acid residues linked by peptide bonds, are ubiquitous in living organisms and serve critical biological functions. Key roles include acting as hormones, neurotransmitters, immune regulators, and antimicrobial agents. Their small size enables peptides to play indispensable roles in cellular signaling, immune modulation, and growth......
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• Selected Reaction Monitoring
Selected Reaction Monitoring (SRM) is a mass spectrometry-based quantitative technique extensively utilized in proteomics research. By targeting specific precursor ions and their corresponding product ions, SRM achieves exceptional sensitivity and specificity in detecting analytes. Initially developed for small molecule analysis, its application has expanded significantly due to its robustness in quantifying components within complex biological samples. In proteomics, Selected Reaction Monitoring is a......
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• De Novo Peptide Sequencing in Proteomics Applications
De novo peptide sequencing is a technique used to directly infer the amino acid sequence of unidentified peptide fragments from mass spectrometry data. Unlike traditional database search methods, it does not rely on pre-existing protein sequence databases. Instead, it derives peptide sequences by analyzing the fragmentation patterns of ions present in the mass spectrometry data. This technology plays a pivotal role in proteomics research, particularly for investigating newly discovered proteins, speci......
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Isotope labeling-based relative and absolute quantification (iTRAQ) is a technique that enables the relative and absolute quantification analysis of multiple samples through isotope labeling. The core of iTRAQ technology lies in using chemical labeling reagents to label proteins. These reagents react with the N-terminus of peptide chains and the side chain of lysine, creating a unique labeling pattern that allows the same peptide to be distinguished and quantified by mass spectrometry across different......
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• Dynamic Light Scattering Service
Dynamic light scattering service is a specialized analytical technique used for particle analysis, relying on dynamic light scattering (DLS) technology. This service is widely applied in the determination of particle size distribution and molecular dynamics studies, particularly for nanomaterials, biomolecules, and other particulate systems. The dynamic light scattering service has become an indispensable tool due to its simplicity, speed, and high sensitivity, especially when investigating nanopartic......
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Chemoproteomics is an interdisciplinary field that integrates chemical tools with proteomics techniques, aiming to provide a comprehensive analysis of protein structure, function, and their interactions with small molecules. The core principle of chemoproteomics involves using chemical probes or reactive molecules to specifically label proteins or their modification sites, which can then be detected using high-throughput techniques such as mass spectrometry. These labels enable the analysis of related......
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• Protein-Protein Interaction in Biological Processes
Protein-protein interaction (PPI) refers to the process by which two or more protein molecules form complexes through non-covalent binding. This interaction is fundamental to nearly all biological processes within living organisms. Proteins are the primary functional molecules in cells, performing critical roles such as enzyme catalysis, signal transduction, structural support, and material transport. Within each cell, a complex network of interactions coordinates diverse biological activities. For in......
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Amino acid test aims to accurately measure the content and composition of amino acids in biological samples. As the core constituents of proteins, amino acids play an essential role in biological processes. Consequently, their precise quantification is vital for both life science research and clinical diagnostics. Amino acid testing helps researchers gain a deeper understanding of protein structure, function, and metabolic pathways, and it has broad applications across various fields. Through accurate......
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Metabolomics and proteomics provide complementary insights into biological activities at the molecular level, with metabolomics focusing on small molecule metabolites and proteomics on proteins. These two fields are fundamental to modern biological research. Metabolomics studies metabolites, which are intermediate or final products of biochemical reactions. The dynamic fluctuations in metabolite levels reflect cellular metabolic states and responses to environmental changes. By analyzing the types, co......
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SWATH mass spectrometry is an advanced data-independent acquisition technique that has attracted considerable attention in proteomics research in recent years. This technology addresses the challenge of inadequate coverage of low-abundance proteins in traditional data-dependent acquisition approaches by fragmenting all ions within a predefined mass range. The introduction of this technique has significantly enhanced the coverage and reproducibility of quantitative proteomics data, as well as improved ......
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