Resources

• • De Novo Sequencing for Protein Structure and Function Analysis

  "De novo" (from scratch) sequencing is a technique used to determine the amino acid sequence of new or unknown proteins or peptides. This method is particularly useful for proteins or peptides that are not present in existing databases.

• • Analysis of Impurities in Recombinant Protein Drug Products

  Recombinant protein drugs are biopharmaceutical products produced by engineered cells, with complex molecular structures and relatively complex manufacturing processes. During the production process, not only process-related impurities such as host cell proteins and DNA residues may be generated, but also product-related impurities may be produced. These product-related impurities mainly include degradation products, aggregates, and variants.

• • Determination of Antibody Drug Protein Concentration

  Antibody drugs are a class of drugs that are artificially synthesized antibodies used to treat diseases. They achieve therapeutic effects by specifically binding to target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates.

• • UV Spectral Analysis of Recombinant Protein Vaccines

  Recombinant protein vaccines are a type of vaccines that do not contain complete pathogens and are formulated with specific protein antigens produced by heterologous expression systems. Recombinant protein vaccines have gained wide attention from researchers in recent years due to their advantages of good safety, strong stability, and relatively low cost.

• • Chiral Isomer Analysis of Peptide Drugs

  Peptide drugs are biologically active molecules composed of multiple amino acids connected by peptide bonds. Typically, they consist of 10 to 100 amino acids and have a relative molecular weight lower than 10,000. Peptide drugs have shown great potential in treating various diseases, such as cancer, autoimmune diseases, and metabolic disorders.

• • Nuclear Magnetic Resonance Analysis of Recombinant Protein Vaccines

  Recombinant protein vaccines are a class of vaccines that do not contain complete pathogens and are formulated with specific protein antigens produced by heterologous expression systems. Common heterologous expression systems include bacteria, mammalian cells, plant cells, and insect cells, among which the appropriate heterologous expression system is selected based on the type of antigen produced.

• • Analysis of Glycoproteins in Nasopharyngeal Carcinoma Tissues

  Nasopharyngeal carcinoma is one of the common malignant tumors in the head and neck region, with its incidence and mortality rates continuously rising in recent years. In order to gain a deeper understanding of the pathogenesis, diagnosis, and treatment of nasopharyngeal carcinoma, the analysis of glycoproteins in nasopharyngeal carcinoma tissues is crucial.

• • Analysis of N-Glycosylation and Modification Sites in Liver Tissues

  The liver is the main metabolic organ in the human body, responsible for a significant amount of biotransformation and excretion functions. Protein glycosylation, particularly N-glycosylation, in liver cells is crucial for ensuring normal liver function. This modification not only affects the stability, function, and interactions of proteins, but also plays a central role in liver diseases such as cirrhosis, hepatitis, and liver cancer.

• • Mechanism of Edman Degradation in Protein Sequencing

  The core of the Edman degradation method lies in its unique chemical reaction mechanism, which efficiently and accurately isolates and identifies N-terminal amino acids.

• • Application of Edman Degradation in Protein Analysis

  The Edman degradation method is a classic protein analysis technique, primarily used to determine N-terminal amino acid sequences. Developed by Pehr Edman in the 1950s, this method has been crucial in protein chemistry. Although modern mass spectrometry dominates high-throughput proteomics, Edman degradation remains uniquely valuable in specific applications due to its precision and reliability.