Resources

Proteomics Databases



Metabolomics Databases

• • Peptidomic Analysis

  Peptidomic analysis, a subdivision of proteomics, is dedicated to examining peptide molecules within biological samples. Peptides, typically consisting of 2 to 50 amino acids linked by peptide bonds, are crucial in various biological functions such as cellular signaling, immune responses, and hormone regulation. The primary objective of peptidomic analysis is to thoroughly investigate peptide sequences, concentrations, and modifications within biological samples, thereby uncovering their roles and dyn......

• • Peptide Sequence Analysis by Tandem Mass Spectrometry

  Peptide Sequence Analysis by Tandem Mass Spectrometry is a powerful analytical tool employing multi-stage mass spectrometry techniques to characterize peptide molecules. Through MS/MS, scientists can elucidate peptide sequences within complex protein samples, thereby facilitating the study of protein biological functions, the identification of novel proteins, exploration of protein post-translational modifications, and the development of novel biomarkers. Biomarkers serve as molecular indicators of bi......

• • Peptide Identification: Unlocking Protein Composition

  Peptide identification is a fundamental step in proteomics research, involving the determination and confirmation of amino acid sequences of peptides in samples using mass spectrometry or other analytical techniques. Peptides, which are short chains of amino acids linked by peptide bonds, are the basic units of proteins. In proteomics, this process is primarily utilized to analyze the protein composition within complex biological samples. By determining the sequences of peptides, researchers can infer......

• • PAGE Protein Analysis

  PAGE Protein Analysis is a classical and widely implemented analytical technique for protein analysis. This method relies on the variable migration rates of proteins through a polyacrylamide gel under an electric field, effectively enabling the separation of proteins within a complex mixture. The fundamental principle underlying this technique is that a protein's migration speed in an electric field correlates with its molecular weight, shape, and charge density. Through PAGE Protein Analysis, researc......

• • Methionine Oxidation Mass Spectrometry

  Methionine oxidation mass spectrometry is a specialized technique used to detect and analyze the oxidation of methionine residues in proteins. Methionine, a sulfur-containing amino acid found abundantly in proteins, is prone to oxidation, which allows it to play a crucial regulatory role in biological systems. The oxidation of methionine can alter protein function, influencing cell signaling, protein folding, and enzyme activity. By assessing the oxidation state of methionine in protein samples, this ......

• • MALDI-TOF MS Protein Analysis

  MALDI-TOF MS protein analysis is a robust method for protein analysis, allowing high-throughput examination of proteins in complex biological samples. MALDI-TOF MS protein analysis has significant applications across multiple fields. In proteomics, MALDI-TOF MS facilitates protein identification and sequence analysis by comparing data with existing databases, aiding in the discovery of disease biomarkers and elucidation of protein functionalities. Clinically, this method enables rapid identification o......

• • Glycan Analysis of Therapeutic Glycoproteins

  Glycan analysis of therapeutic glycoproteins is pivotal in modern biomedical research. Glycoproteins, composed of proteins and carbohydrate chains, play essential roles in cell recognition, signal transduction, and immune responses. In therapeutic contexts, many drugs, including monoclonal antibodies and fusion proteins, are glycoproteins. The analysis of glycans aids in evaluating and mitigating the immunogenicity risks associated with therapeutic glycoproteins. Glycan analysis involves the detailed ......

• • Bottom-Up and Top-Down Proteomics

  Bottom-up and top-down proteomics represent two key methodologies in proteomics research, aimed at decoding protein structure, function, and interactions. In bottom-up proteomics, proteins are enzymatically digested into smaller peptides. These peptides are then analyzed using sensitive techniques like mass spectrometry to identify and quantify them. The essence of this method lies in deducing the properties and functions of entire proteins from peptide data. Consequently, bottom-up proteomics is exte......

• • Qualitative Analysis of Amino Acid

  Qualitative analysis of amino acid involves identifying different types of amino acids within biological samples through advanced separation and detection methods. These analyses help elucidate the compositional characteristics and biological functions of amino acids, which are the fundamental units of proteins involved in constructing cellular structures, regulating metabolic pathways, and facilitating neural conduction and signal transmission. Variations in amino acid types and their relative concen......

• • Mass Spectrometry Phosphorylation Site Analysis

  Mass spectrometry phosphorylation site analysis is a powerful technique based on mass spectrometry for identifying and examining phosphorylation sites in proteins. As the most prevalent post-translational modification (PTM), phosphorylation regulates protein activity, stability, and molecular interactions. This modification allows cells to swiftly respond to external stimuli and modulate signaling pathways. Through precise identification of phosphorylation sites, this technique provides critical insig......