What Does 'Pan-Cancer' Mean in Pan-Cancer Analysis?
The term "pan-cancer" is a relatively recent concept frequently used in cancer genomics and transcriptomics research. It refers to an integrative analysis spanning multiple cancer types or subtypes, rather than focusing on a single cancer type. The primary goal of pan-cancer analysis is to identify shared genes, pathways, biomarkers, or other molecular features across diverse cancer types, potentially governed by common molecular mechanisms or biological processes.
One of the most prominent initiatives conducting pan-cancer analysis is The Cancer Genome Atlas (TCGA), which has analyzed thousands of tumor samples covering a wide range of cancer types. The availability of such large-scale datasets enables researchers to apply bioinformatics and statistical approaches to uncover complex patterns and interconnections across different cancers, thereby advancing our understanding of cancer biology, improving diagnostic strategies, and informing therapeutic development.
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